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Roles of ghrelin in left-ventricular remodelling after acute myocardial infarction
  1. Hideyuki Kondo1,
  2. Yukihiro Hojo1,
  3. Nozomu Takahashi1,
  4. Tomokazu Ikemoto1,
  5. Hirotaka Aoki1,
  6. Katsuya Dezaki2,
  7. Kazuomi Kario1,
  8. Takaaki Katsuki1,
  9. Toshihiko Yada2,
  10. Kazuyuki Shimada1
  1. 1Department of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan
  2. 2Division of Integrative Physiology, Department of Physiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan
  1. Correspondence to Dr Yukihiro Hojo, Department of Cardiology, Jichi Medical University, 3311 Yakushiji, Shimotsuke-city, Tochigi 329-0498, Japan; yhojo{at}jichi.ac.jp

Abstract

Objective The purpose of this study was to elucidate the role of ghrelin after acute myocardial infarction (AMI) in left ventricular (LV) remodelling.

Design Prospective observational study.

Setting Jichi Medical University Hospital.

Patients Fifty consecutive patients experiencing their first AMI.

Interventions Ghrelin was measured on the day of admission, day 7, day 14 and 6 months after AMI. Patients were treated by percutaneous coronary intervention, and successful myocardial reperfusion was accomplished within 12 h after onset. To analyse LV remodelling, the authors performed left ventriculographies on the day of admission and 6 months after AMI.

Main outcome measures Changes in LV volume.

Results Plasma ghrelin increased significantly after AMI (admission: 40.9±7.3; day 7: 89.5±11.0; day 14: 92.6±11.8 fmol/ml, p<0.0001). There was a significant correlation between ghrelin on day 14 and changes in LV volume over 6 months (r=+0.46, p<0.001). Multivariate regression analysis showed that ghrelin on day 14 is a significant predictor of LV remodelling after AMI (β=+0.44, p=0.001).

Conclusion To our knowledge, this is the first report that shows a relation between circulating ghrelin after AMI and the progression of LV remodelling in the chronic phase. The elevation of ghrelin after AMI might be a compensatory mechanism to attenuate LV remodelling.

  • Acute coronary syndromes
  • Acute coronary syndrome
  • Ghrelin
  • Metabolism
  • Myocardial ischaemia
  • Ventricular remodelling
  • AMI
  • acute myocardial infarction
  • BMI
  • body mass index
  • CPK-AUC
  • creatine phosphokinase-area under the curve
  • CRP
  • C-reactive protein
  • GH
  • growth hormone
  • IGF-1
  • insulin-like growth factor-1
  • LV
  • left ventricular
  • LVEDVI
  • left ventricular end-diastolic volume index
  • LVEF
  • left ventricular ejection fraction
  • PCI
  • percutaneous coronary intervention

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Footnotes

  • Competing interests None.

  • Ethics approval Ethics approval was provided by the Ethics Committee of Jichi Medical University.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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