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The number and function of circulating CD34+CD133+ progenitor cells decreased in stable coronary artery disease but not in acute myocardial infarction
  1. Takahisa Kondo1,
  2. Satoshi Shintani1,
  3. Kengo Maeda1,
  4. Mutsuharu Hayashi1,
  5. Yasuya Inden1,
  6. Yasushi Numaguchi1,
  7. Kaichiro Sugiura1,
  8. Yasuhiro Morita1,
  9. Tomoya Kitamura1,
  10. Haruo Kamiya2,
  11. Takahito Sone3,
  12. Miyoshi Ohno2,
  13. Toyoaki Murohara1
  1. 1Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
  2. 2Department of Cardiology, Japanese Red Cross Nagoya Daiichi Hospital, Japan
  3. 3Department of Cardiology, Ogaki Municipal Hospital, Ogaki, Japan
  1. Correspondence to Dr Takahisa Kondo, Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-8550, Japan; takahisa{at}med.nagoya-u.ac.jp

Abstract

Objective Circulating CD34+CD133+ cells are one of the main sources of circulating endothelial progenitor cells (EPCs). Age is inversely related to the number and function of CD34+CD133+ progenitor cells in stable coronary artery disease (CAD), but the relationship remains unclear in acute myocardial infarction (AMI). The authors aimed to clarify how ageing affects the number and function of mobilised CD34+CD133+ progenitor cells in AMI.

Design and results Circulating CD34+CD133+ progenitor cells were measured by flow cytometry. Measurements were made at admission for CAD, or on day 7 after the onset of AMI. In stable CAD (n=131), circulating CD34+CD133+ cells decreased with age (r=−0.344, p<0.0001). In AMI, circulating CD34+CD133+ cells did not correlate with age (n=50), and multivariate analysis revealed that the decreased number of circulating CD34+CD133+ cells was associated with male sex and higher peak creatinine kinase. The ability to give rise to functional EPCs, which show good migratory and tube-forming capabilities, deteriorated among stable CAD subjects (n=10) compared with AMI subjects (N=6).

Conclusions In stable CAD, the number and function of circulating CD34+CD133+ progenitor cells decreased with age, whereas those mobilised and circulating in AMI did not.

  • CD34
  • CD133
  • EPCs
  • chronic stable angina
  • acute myocardial infarction
  • age
  • angina—stable
  • vascular biology
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Footnotes

  • Funding This work was supported by grants from Nagoya University Graduate School of Medicine, and a grant from the Smoking Research Foundation.

  • Competing interests None.

  • Ethics approval Ethics approval was provided by the ethical committee of Nagoya University Graduate School of Medicine (Institutional No 68).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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