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The medical treatment of endomyocardial fibrosis in 2009
  1. Kunju M Subair1,
  2. Prabha Nini Gupta1,
  3. K Suresh1,
  4. K R Santhosh1,
  5. Preetham Kumar Francis1,
  6. Thomas John1,
  7. Preeti Sara George2
  1. 1Medical College Hospital (MCH), Trivandrum, India
  2. 2Regional Cancer Centre, Trivandrum, India
  1. Correspondence to Dr Professor Prabha Nini Gupta, MCH, T/C 5/2091, Near the Srikrishna Temple, Cheruvekkal, Srikaryam, Trivandrum 695017, Kerala, India; ninigupta{at}gmail.com

Abstract

Objectives To study the natural history of medically treated patients with endomyocardial fibrosis (EMF) and to see whether the usage of common drugs affected survival.

Design A real-world all-comers analysis with follow-up.

Setting A teaching hospital.

Analysis Cox proportional hazards multiple regression and Kaplan–Meier curves for survival with both univariate and multivariate analysis.

Results The mean age of this population was 40.5±5 years at first symptom. The mortality was also less than previous reports at 10.38%. The dominant type of EMF was dominant left ventricular EMF in 49, right ventricular EMF in 52 and biventricular EMF in 53. On univariate analysis by Kaplan–Meier curves and log-rank test patients on warfarin had a better survival (at 5, 10 and 15 years—97.3, 87.54% and 87.54%, respectively) compared with no warfarin at 5, 10 and 15 years (91.37%, 88.9% and 66.68%), log rank test NS. On multivariate analysis when sex, the presence of complications, use of ACE inhibitors, use of aldactone, use of digoxin, frusemide and warfarin and age (age at entering the study) were entered into the analysis, the following results were obtained—men had a shorter time to death. Furthermore, when patients taking aldactone and those not taking aldactone were examined it was found that those on aldactone had a higher mortality and shorter time to death.

Conclusion On analysis of the usage of warfarin, those not on it had a shorter time to death; likewise did older patients.

  • ACE inhibitors
  • anticoagulation
  • cardiomyopathy restrictive
  • diuretics
  • endomyocardial fibrosis
  • medical treatment
  • natural history
  • survival

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Footnotes

  • Competing interests None.

  • Ethics approval The study received ethics approval from the institutional ethics committee of the Medical College Hospital, Trivandrum, India.

  • Provenance and peer review Not commissioned; not externally peer reviewed.

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