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The relationship between the number of preprocedural circulating endothelial progenitor cells and angiographic restenosis following coronary artery stent placement
  1. Margo Klomp1,
  2. Claudia M van Tiel2,
  3. Anita M Klous2,
  4. Marcel A M Beijk1,
  5. Margriet I Klees1,
  6. Esther M Scheunhage1,
  7. Jan G P Tijssen1,
  8. Carlie J M de Vries2,
  9. Robbert J de Winter1
  1. 1Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
  2. 2Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
  1. Correspondence to Margo Klomp, Department of Cardiology, Academic Medical Center, University of Amsterdam, Room B2-136, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; m.klomp{at}amc.uva.nl

Abstract

Objective In animals, endothelial progenitor cells (EPCs) beneficially influence the repair of the coronary vessel wall after damage by stent placement. However, their role in humans is less well understood. In the present study, the authors aimed to evaluate the relationship between the number of preprocedural EPCs defined as CD34+/KDR+/CD133+ cells and angiographic late loss as a measure of the growth of in-stent intimal hyperplasia.

Design, setting, patients and interventions The 59 study patients were treated in the authors' clinic with a Genous EPC capturing stent, a bare metal stent (BMS) or a drug-eluting stent, and angiographic follow-up occurred between 6 and 13 months.

Results The authors found no relationship between preprocedural EPCs and angiographic late loss, irrespective of stent type. Though statistically not significant, patients with a high number of preprocedural CD34 cells and treated with a Genous stent or BMS showed a numerically higher late loss (in Genous patients: 1.03±0.76 mm vs 0.71±0.50 mm, p=0.15; in BMS patients: 1.06±0.73 mm vs 0.35±0.62 mm, p=0.08).

Conclusions Considering these and other varied observations, further studies aimed at identifying the biological mechanism and the individual roles of EPCs and/or CD34 cells in endothelial repair after coronary vessel stenting are needed.

  • Endothelial cells
  • PTCA
  • QCA
  • stents

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Footnotes

  • Funding The Academic Medical Center-Amsterdam received an unrestricted educational grant from OrbusNeich to conduct the TRI-stent adjudication study programme. Funding for assessment of endothelial progenitor cells and other cell populations and lab staff came from various academic sources at the Academic Medical Center.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics approval was provided by the Medical Ethic Committee of the Academic Medical Center-University of Amsterdam.

  • Provenance and peer review Not commissioned; not externally peer reviewed.

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