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Type 2 diabetes and cardiovascular diseases: do they share a common soil? The Asian Indian experience
  1. Rajendra Pradeepa,
  2. Adamsha Nazir,
  3. Viswanathan Mohan
  1. Dr Mohan's Diabetes Specialities Centre, Madras Diabetes Research Foundation, Gopalapuram, Chennai, India
  1. Correspondence to Dr Viswanathan Mohan, Director and Chief of Diabetes Research, Madras Diabetes Research Foundation, Dr Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Noncommunicable Diseases, Prevention and Control, 4, Conran Smith road, Gopalapuram, Chennai 600 086, India; mvdsc{at}vsnl.com

Abstract

In India, diabetes and cardiovascular disease (CVD) are growing health problems. CVD accounts for much of the increased morbidity and premature mortality associated with type 2 diabetes. Moreover, CVD also occurs 2–3 decades earlier among diabetic subjects and runs a more aggressive course and has a worse prognosis. The pathophysiology of the link between diabetes and CVD is complex and multifactorial and understanding the mechanisms of the disease can help identify and treat CVD in patients with diabetes and vice versa. The current article reviews the common antecedents between type 2 diabetes and CVD including non-modifiable and modifiable risk factors and suggests that future research on diabetes and CVD should focus on searching for risk factors for CVD that may be more specific to diabetes, such as hypoglycaemia or medication related comorbidities. Also, the authors recommend research on common genetic variants which might have stronger effects and hence have a potential role in diabetes and CVD risk prediction. Finally, primary prevention trials trying to prevent both diabetes and CVD are the urgent need of the hour!

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Footnotes

  • Competing interest None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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