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A meta-analysis of proinflammatory cytokines in chronic heart failure
  1. Mao Liu1,
  2. Jian Chen1,
  3. Dan Huang1,
  4. Jianting Ke2,
  5. Wei Wu1
  1. 1Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, People's Republic of China
  2. 2Department of Nephrology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, People's Republic of China
  1. Correspondence to Professor Wei Wu, Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52, Meihua East Rd, Zhuhai 519000, People's Republic of China; wu.wei{at}medmail.com.cn

Abstract

Background Previous studies suggested that inflammation was involved in chronic heart failure (CHF), but their sample sizes were small.

Objective To summarise the clinical cytokine data systematically and emphasise the importance of proinflammatory cytokines in the pathogenesis of CHF, we conducted a meta-analysis of relevant literatures.

Methods Articles about cytokines and CHF were searched in Pubmed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure and Chinese Wanfang Database. The pooled effects were measured by weighted mean difference (MD) and 95% CI, which were calculated by RevMan 5.1 software.

Results Finally, a total of 28 studies were included. Compared with normal control subjects, concentrations of tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1β and C reactive protein (CRP) in the peripheral blood in CHF patients are significantly increased. The overall MDs with 95% CIs for TNF-α, IL-6, CRP and IL-1β were 2.59 pg/ml (2.14∼3.05, p<0.00001), 5.49 pg/mL (4.68∼6.29, p<0.00001), 11.45 mg/dL (7.68∼15.23, p<0.00001) and 0.11 pg/mL (0.09∼0.14, p<0.00001). The mortality of elevated IL-6 group was significantly higher than control group (OR=6.73, 95% CI 2.39∼18.93, p=0.0003).

Conclusions Concentrations of TNF-α, IL-6, IL-1β and CRP are significantly higher in CHF patients than in control subjects. Proinflammatory cytokines play an import role in the pathogenesis of CHF.

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