Article Text

PDF
Influence of ApoB100 3′ hypervariable repeats on acute myocardial infarction
  1. Neha Singh1,
  2. Nakul Sinha2,
  3. Sudeep Kumar1,
  4. Chandra M Pandey3,
  5. Suraksha Agrawal4
  1. 1Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
  2. 2Sahara Hospital, Department of Cardiology, Lucknow, Uttar Pradesh, India
  3. 3Department of Biostatistics and Health Informatics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
  4. 4Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
  1. Correspondence to Dr Neha Singh, 440 Veteran Avenue, Los Angeles, CA 90024, USA; senger.neha{at}gmail.com

Abstract

Background and objective The 3′ flanking region of apolipoprotein B (ApoB) 100 gene is known to contain short A+T-rich DNA sequences which are hypervariable in nature and called the variable number of tandem repeats (VNTRs). It results in different alleles of ApoB100. The present study extends the investigation of whether there is a correlation between the presence of these alleles and acute myocardial infarction (MI).

Methods We examined ApoB genotypes in 230 acute MI patients and 300 healthy controls. PCR based genotyping was done for ApoB 3′ VNTRs.

Results We recoded 3′ApoB-VNTR alleles through three- and five-allelic models based on different sizes and found that large repeats (>37) were significantly associated with acute MI (p<0.0001). These large repeats (>37) were also significantly associated with higher lipid levels in the MI group.

Conclusion Patients with 3′ApoB-VNTR large repeats (>37) are more susceptible to acute MI development.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.