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Heart Asia 6:83-86 doi:10.1136/heartasia-2013-010457
  • Original research

Systolic blood pressure during recovery from exercise is related to flow-mediated dilatation in patients with coronary artery disease

  1. Hisao Ikeda
  1. Department of Cardiology, Kurume University Medical Center, Kurume, Kumamoto, Japan
  1. Correspondence to Dr Yasuhiro Nishiyama, Department of Cardiology, Kurume University Medical Center, 115-4 Waifu, Kikuchi, Kumamoto 861-1331, Japan; ynishi{at}orange.ocn.ne.jp
  • Received 10 October 2013
  • Revised 7 April 2014
  • Accepted 18 May 2014

Abstract

Objective To assess the relationship between exercise-induced parameters obtained from the routine exercise stress testing (EST) and flow-mediated vasodilatation (FMD) as an index of endothelial function.

Design A retrospective study.

Setting Kurume University Medical Center, Kurume, Japan.

Patients All patients with stable coronary artery disease (CAD) who were admitted to Kurume University Medical Center.

Main outcome measure Results of EST and FMD.

Results We studied 66 patients (35 male/31 female) with CAD. All patients underwent symptom-limited EST and measurement of FMD. Exercise parameters included exercise-induced heart rate and systolic blood pressure (SBP). FMD did not differ between male and female groups. In univariate analysis, determinants of FMD included age and the change in SBP at 1 min after exercise. In Cox hazard model analysis, the change in SBP at 1 min after exercise (p=0.011) was an independent determinant of FMD. FMD in patients with abnormal SBP response group was significantly lower than that in normal SBP response group (4.2±1.8 ns. 6.1±2.6%, p<0.05).

Conclusions These findings suggest that SBP during recovery from exercise is associated with endothelial function in patients with CAD.

"The publication of a premier cardiology journal, Heart Asia, by BMJ Publishing Group is a significant step forwards as this will become the preferred journal of choice for many of the original research work in the Asia Pacific region,"

Professor Vinay K Bahl, All India Institute of Medical Sciences, New Delhi

"The launch of Heart Asia will provide doctors in China a platform to publish their original research data and it is an important bridge that will allow the Chinese cardiologists to integrate with the international cardiology community,"

Professor Hu Dayi, Chief of the Heart Centre at Peking University’s People’s Hospital, Beijing

"Leading cardiology centres in the Asia Pacific region do some of the finest research in the world and the launch of Heart Asia is timely as it will allow top class research papers to be published in an Asia Pacific cardiology journal,"

Professor Ruey Jen Sung, Professor, Emeritus, Stanford University.

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