Article Text
Abstract
Objective High-sensitivity troponin (hs-Tn) assays need to be applied appropriately to improve diagnosis and patient outcomes in acute coronary syndromes (ACS).
Methods Experts from Asia Pacific convened in 2015 to provide data-driven consensus-based, region-specific recommendations and develop an algorithm for the appropriate incorporation of this assay into the ACS assessment and treatment pathway.
Results Nine recommendations were developed by the expert panel: (1) troponin is the preferred cardiac biomarker for diagnostic assessment of ACS and is indicated for patients with symptoms of possible ACS; (2) hs-Tn assays are recommended; (3) serial testing is required for all patients; (4) testing should be performed at presentation and 3 hours later; (5) gender-specific cut-off values should be used for hs-Tn I assays; (6) hs-Tn I level >10 times the upper limit of normal should be considered to ‘rule in’ a diagnosis of ACS; (7) dynamic change >50% in hs-Tn I level from presentation to 3-hour retest identifies patients at high risk for ACS; (8) where only point-of-care testing is available, patients with elevated readings should be considered at high risk, while patients with low/undetectable readings should be retested after 6 hours or sent for laboratory testing and (9) regular education on the appropriate use of troponin tests is essential.
Conclusions We propose an algorithm that will potentially reduce delays in discharge by the accurate ‘rule out’ of non-ACS patients within 3 hours. Appropriate research should be undertaken to ensure the efficacy and safety of the algorithm in clinical practice, with the long-term goal of improvement of care of patients with ACS in Asia Pacific.
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Contributors Category 1—Conception and design of study: JWCT, LC, MI-D, W-TC; Acquisition of data: TCA, CSPL, KHY, AP, SSM; Analysis and/or interpretation of data: JMA, VPD, TAMC, PT, KHC. Category 2—Drafting the manuscript: JWCT, CSPL, LC; Revising the manuscript critically for important intellectual content: JWCT, CSPL, SSK, TCA, JMA, WTC, VPD, MI-D, SSM, AP, TAMC, PT, KHY, LC. Category 3—Approval of the version of the manuscript to be published: JWCT, CSPL, SSK, TCA, JMA, WTC, VPD, MI-D, SSM, AP, TAMC, PT, KHY, LC.
Funding Abbott Laboratories (Singapore) Pte provided logistic support and funding for the Asia Pacific Troponin Advisory Board Meeting and MIMS Pte to provide editorial support.
Competing interests All authors were provided with logistical support to attend the advisory board meeting. In addition, LC has received institutional research grants and honorarium from Roche, Abbott Diagnostics, Alere, Siemens and Radiometer Pacific. CSPL is supported by a Clinician Scientist Award from the National Medical Research Council of Singapore; has received research support from Boston Scientific, Bayer, Thermofisher, Medtronic and Vifor Pharma and has consulted for Bayer, Novartis, Takeda, Merck, Astra Zeneca, Janssen Research & Development, LLC, Menarini, Boehringer Ingelheim and Abbott.
Provenance and peer review Not commissioned; externally peer reviewed.