Objective To examine the association between loci linked to high-density lipoprotein cholesterol (HDL-C) levels and coronary artery disease (CAD).
Methods A pilot study consisting of age-matched and gender-matched angiographically confirmed CAD cases (n=150) and non-CAD controls (n=150) was performed to test an association. Illumina's Human Cardio-Metabo BeadChip containing 3112 variants associated with HDL-C levels was used for genotyping.
Results A preliminary analysis identified 36 variants from 16 genes that were statistically significant (p<0.05) between cases and controls. However, none of the variants remained statistically significant after correction for multiple testing. Besides, variants rs11039159 (MADD), rs749067 (MADD), rs367070 (LILRA3) and rs330921 (PPP1R3B) showed modest association with HDL-C levels.
Conclusions None of the HDL-C associated loci included in this study were found to be a significant risk factor for CAD. However, the study could replicate the findings of four variants influencing HDL-C levels.
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Contributors Study conception and design: TFA, AS, CKP, RMR; Data Collection: AS, CKP, RMR; Experimental work and data analysis: AS; Manuscript writing: AS, TFA; Approval of final version: TFA, AS, CKP, RMR.
Funding The project was funded by National Health & Education Society, P.D. Hinduja Hospital & MRC, Mumbai, India.
Competing interests None declared.
Ethics approval IRB, PD Hinduja Hospital & MRC.
Provenance and peer review Not commissioned; externally peer reviewed.
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