RT Journal Article
SR Electronic
T1 The number and function of circulating CD34<sup>+</sup>CD133<sup>+</sup> progenitor cells decreased in stable coronary artery disease but not in acute myocardial infarction
JF Heart Asia
JO Heart Asia
FD BMJ Publishing Group Ltd, British Cardiovascular Society and Asia Pacific Heart Association
SP 20
OP 23
DO 10.1136/ha.2009.001644
VO 2
IS 1
A1 Takahisa Kondo
A1 Satoshi Shintani
A1 Kengo Maeda
A1 Mutsuharu Hayashi
A1 Yasuya Inden
A1 Yasushi Numaguchi
A1 Kaichiro Sugiura
A1 Yasuhiro Morita
A1 Tomoya Kitamura
A1 Haruo Kamiya
A1 Takahito Sone
A1 Miyoshi Ohno
A1 Toyoaki Murohara
YR 2010
UL http://heartasia.bmj.com/content/2/1/20.abstract
AB Objective Circulating CD34+CD133+ cells are one of the main sources of circulating endothelial progenitor cells (EPCs). Age is inversely related to the number and function of CD34+CD133+ progenitor cells in stable coronary artery disease (CAD), but the relationship remains unclear in acute myocardial infarction (AMI). The authors aimed to clarify how ageing affects the number and function of mobilised CD34+CD133+ progenitor cells in AMI.Design and results Circulating CD34+CD133+ progenitor cells were measured by flow cytometry. Measurements were made at admission for CAD, or on day 7 after the onset of AMI. In stable CAD (n=131), circulating CD34+CD133+ cells decreased with age (r=−0.344, p&lt;0.0001). In AMI, circulating CD34+CD133+ cells did not correlate with age (n=50), and multivariate analysis revealed that the decreased number of circulating CD34+CD133+ cells was associated with male sex and higher peak creatinine kinase. The ability to give rise to functional EPCs, which show good migratory and tube-forming capabilities, deteriorated among stable CAD subjects (n=10) compared with AMI subjects (N=6).Conclusions In stable CAD, the number and function of circulating CD34+CD133+ progenitor cells decreased with age, whereas those mobilised and circulating in AMI did not.