Showing demographic characteristics, clinical features, and management of identified patients with Interferon related pericardial injury
| n | Author year | Age/sex | Presenting complaints | Clinical findings | CXR | Associated problems | Diagnostic evaluation | Treatment | Outcome | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ECG | TTE | Chest CT scan | DPC | PBx | Conservative | TPC | Pericardial window | ||||||||
| 1 | Fava, 1996 | 28/NA | Chest pain | NA | NA | NA | Modest PE | NA | NA | NA | INF D/C prednisone | NA | NA | PE resolved relapse with reuse | |
| 2 | Boonen, 1999 | 24/F | Left shoulder pain, fever, fatigue | PFR | NA | NA | NA | NA | NA | NA | Prednisone, chloroquine | NA | NA | PE resolved relapsed with reuse×3 | |
| 3 | Gressens, 2004 | 40/F | LE oedema, SOB, | B/L LE oedema | NA | Sensory neuropathy | Non specific ST changes | PE without temponade | NA | NA | NA | INF D/C aspirin | NA | NA | PE Resolved |
| 4 | Benjamini, 2007 | 63/M | Chest pain, SOB | PFR | CMG B/L PLE | Bilateral PLE CHF | NA | Global systolic dysfunction | NA | NA | NA | Dexamethasone furosemide | NA | NA | Pericarditis resolved and CHF improved |
| 5 | Nishoi, 2010 | 67/M | SOB, B/L LE oedema | B/L LE oedema | CMG BL PLE | B/L PLE DPN | ST elevation (V1-V6) | Moderate PE | PE, PLE | NA | NA | INF D/C prednisone, chloroquine IVIG, furosemide | NA | NA | Pericarditis resolved and DNP improved |
| 6 | Popescu, 2011 | 38/F | Chest pain, SOB, fatigue | Muffled heart sounds | N | N | PE without tamponade | NA | NA | NA | INF D/CI ibuprofen | NA | NA | PE resolved recurrence with reuse and resolution on D/C | |
| 7 | Rauw, 2012 | 31/F | Chest pain, SOB, B/L LE oedema, fatigue | JVD, B/L LE oedema | NA | Low voltage | Moderate PE with tamponade physiology | Moderate PE | yes | NA | INF D/C | yes | NA | PE Resolved | |
| 8 | Hakim, 2013 | 43/M | Chest pain, SOB | N | Left PLE | B/L PLE | N | Moderate to large PE with tamponade | Moderate PE and B/L PLE | Yes | Yes | INF D/C ibuprofen+colchicine steroids | Yes | Yes | Progressed to pericardial constriction |
B/L, bilateral; CHF, congestive heart failure; CXR, chest radiograph; D/C, discontinued; DNP, demyelinating neuropathy; DPC, diagnostic pericardicentesis; F, female; INF, interferon; JVD, jugular venous distension; LE, lower extremity; M, male; n, case number; N, normal; NA, not available; PBx, pericardial biopsy; PE, pericardial effusion; PFR, pericardial friction rub; PLE, pleural effusion; SOB, shortness of breath; ST, ST segment; TPC, therapeutic pericardiocentesis; TTE, transthoracic echocardiogram.