Table 3

Diagnostic performance of the high-sensitivity troponin I (hs-Tn I) assay28

Performance parameter (95% CI)
Patient populationSensitivitySpecificityPPVNPV
>99th percentile on admission (n=1260)82.3 (77.3 to 86.5)92.1 (90.3 to 93.7)75.1 (69.9 to 79.8)94.7 (93.1 to 96.1)
>99th percentile at 3 hours (n=1260)98.2 (95.9 to 99.4)90.4 (88.4 to 92.2)74.7 (69.9 to 79.0)99.4 (98.7 to 99.8)
>99th percentile on admission and hs-Tn I change 0–3 hours (n=1260)50.0 (44.0 to 56.0)99.1 (98.3 to 99.6)94.0 (88.9 to 97.2)87.3 (85.2 to 89.2)
Hs-Tn I change 0–3 hours and hs-Tn I >99th percentile at 3 hours in patients with hs-Tn I <99th percentile on admission (n=951)92.0 (80.8 to 97.8)97.9 (96.7 to 98.7)70.8 (58.2 to 81.4)99.5 (98.8 to 99.9)
  • NPV, negative predictive value; PPV, positive predictive value.