Original ContributionsAngiolymphoid hyperplasia with eosinophilia: Evidence for a T-cell lymphoproliferative origin*
Section snippets
Patients and tissues
Seven formalin-fixed and paraffin-embedded skin biopsies of 7 ALHE patients from the archives of 4 institutions (Departments of Dermatology of University Hospital Zurich, Centre Hospitalier Universitaire Vaudois, and University of Munich and the Department of Pathology, Cantonal Hospital Münsterlingen) were analyzed. The clinical data are given in Table 1. The male-to-female ratio was 6:1, and the median age was 38 years (range, 19 to 66). Eosinophilia of peripheral blood was detected in 2 of
Immunohistochemistry
Analysis of the antigenic phenotypes within the lymphocytic compartment revealed that most (>80%) of the lymphocytic cells (representing about 50% of all inflammatory cells) expressed a CD3+, CD4+, CD43+, and CD45RO+ phenotype, corresponding to the characteristic surface profile of activated T-helper cells (Fig 4).A minority of T cells (10% to 20%) belonged to the CD8+ cytotoxic
Discussion
Using 2 highly specific and sensitive molecular biological methods—PCR-DGGE and AHRFA—clonal populations of T cells were found in 5 of 7 cases of ALHE. PCR-based methods have proven to be reliable and useful tools in the diagnosis of cutaneous T-cell lymphomas (CTCLs), such as mycosis fungoides and Sezary's syndrome, recognizing clonal lymphocytic populations with a sensitivity >90%. Because all neoplasms of nonlymphocytic origin and the vast majority of benign inflammatory diseases are
Acknowledgements
Note Added in Proof. Recently, Chim et al reported the presence of a clonal T-cell population in a case of Kimura's disease (Am J Surg Pathol 2002;26:1083-1086).
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Address correspondence and reprint requests to Werner Kempf, MD, Department of Dermatology, University Hospital Zurich, Zurich, CH-8091, Switzerland.