Abstract
Basilar artery thrombosis has high morbidity and mortality. Though intra-arterial thrombolytics have proven efficacy in the treatment of acute basilar artery occlusion, the elevation of procoagulant factors in the blood after intra-arterial thrombolysis could result in subsequent thrombus formation and clinical deterioration. Glycoprotein IIb/IIIa inhibitors have been shown to reduce this elevation in procoagulants. We present a pilot study of three cases of acute basilar artery occlusion treated with a combination of intra-arterial thrombolytics and Gp IIb/IIIa inhibitor with remarkable clinical recovery seen in all the patients.
MeSH terms
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Adult
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Basilar Artery / diagnostic imaging
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Cerebral Angiography / methods
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Drug Therapy, Combination
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Fibrinolytic Agents / administration & dosage*
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Humans
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Intracranial Thrombosis / drug therapy*
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Intracranial Thrombosis / pathology
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Intracranial Thrombosis / radiotherapy
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Male
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Middle Aged
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Platelet Aggregation Inhibitors / administration & dosage*
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Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
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Tissue Plasminogen Activator / administration & dosage*
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Tomography, X-Ray Computed / methods
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Treatment Outcome
Substances
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Fibrinolytic Agents
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Platelet Aggregation Inhibitors
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Platelet Glycoprotein GPIIb-IIIa Complex
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Tissue Plasminogen Activator