Intra-arterial thrombolysis in basilar artery occlusions combination of intra-arterial thrombolytics and Gp IIb/IIIa inhibitors in basilar artery thrombosis

Neurol India. 2009 May-Jun;57(3):313-9. doi: 10.4103/0028-3886.53291.

Abstract

Basilar artery thrombosis has high morbidity and mortality. Though intra-arterial thrombolytics have proven efficacy in the treatment of acute basilar artery occlusion, the elevation of procoagulant factors in the blood after intra-arterial thrombolysis could result in subsequent thrombus formation and clinical deterioration. Glycoprotein IIb/IIIa inhibitors have been shown to reduce this elevation in procoagulants. We present a pilot study of three cases of acute basilar artery occlusion treated with a combination of intra-arterial thrombolytics and Gp IIb/IIIa inhibitor with remarkable clinical recovery seen in all the patients.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Basilar Artery / diagnostic imaging
  • Cerebral Angiography / methods
  • Drug Therapy, Combination
  • Fibrinolytic Agents / administration & dosage*
  • Humans
  • Intracranial Thrombosis / drug therapy*
  • Intracranial Thrombosis / pathology
  • Intracranial Thrombosis / radiotherapy
  • Male
  • Middle Aged
  • Platelet Aggregation Inhibitors / administration & dosage*
  • Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
  • Tissue Plasminogen Activator / administration & dosage*
  • Tomography, X-Ray Computed / methods
  • Treatment Outcome

Substances

  • Fibrinolytic Agents
  • Platelet Aggregation Inhibitors
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Tissue Plasminogen Activator