Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by
previous studies; however, a large portion of the genetic risk for this disease remains …

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's …

Context Genome-wide association studies (GWAS) have recently identified CLU, PICALM,
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …

ContextMild cognitive impairment (MCI) may be a precursor to dementia, at least in some
cases. Dementia and MCI are associated with neuropsychiatric symptoms in clinical …

Context Ginkgo biloba is widely used for its potential effects on memory and cognition. To
date, adequately powered clinical trials testing the effect of G biloba on dementia incidence …

Background While high adiposity in middle age appears to be related to greater dementia
risk, studies exploring this association in the elderly are conflicting. Objective To evaluate …

The telomere length of replicating somatic cells is inversely correlated with age and has
been reported to be associated cross-sectionally with cardiovascular disease (CVD) …

While previous prospective multicenter studies have conducted cardiovascular disease
surveillance, few have detailed the techniques relating to the ascertainment of and data …

ContextAlcohol consumption has been associated with complex changes in cerebral
vasculature and structure in older adults. How alcohol consumption affects the incidence of …