[HTML][HTML] Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

RC Lai, F Arslan, MM Lee, NSK Sze, A Choo, TS Chen… - Stem cell …, 2010 - Elsevier
Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was
previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury …

Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs

TS Chen, RC Lai, MM Lee, ABH Choo… - Nucleic acids …, 2010 - academic.oup.com
Intercellular exchange of protein and RNA-containing microparticles is an increasingly
important mode of cell–cell communication. Here we investigate if mesenchymal stem cells …

[HTML][HTML] Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium

L Timmers, SK Lim, F Arslan, JS Armstrong, IE Hoefer… - Stem cell …, 2008 - Elsevier
Although paracrine effects of mesenchymal stem cells (MSCs) have been suggested
previously, cardioprotection by human MSC secretions has never been demonstrated …

Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice

Q Lian, Y Zhang, J Zhang, HK Zhang, X Wu, Y Zhang… - Circulation, 2010 - Am Heart Assoc
Background—Aging and aging-related disorders impair the survival and differentiation
potential of bone marrow mesenchymal stem cells (MSCs) and limit their therapeutic …

[HTML][HTML] The gut-skin microbiota axis and its role in diabetic wound healing—a review based on current literature

BK Patel, KH Patel, RY Huang, CN Lee… - International Journal of …, 2022 - mdpi.com
Diabetic foot ulcers (DFU) are a growing concern worldwide as they pose complications in
routine clinical practices such as diagnosis and management. Bacterial interactions on the …

[HTML][HTML] Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

TS Chen, F Arslan, Y Yin, SS Tan, RC Lai… - Journal of translational …, 2011 - Springer
Background Exosomes or secreted bi-lipid vesicles from human ESC-derived mesenchymal
stem cells (hESC-MSCs) have been shown to reduce myocardial ischemia/reperfusion …

[HTML][HTML] Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota

L Tong, H Hao, Z Zhang, Y Lv, X Liang, Q Liu, T Liu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Bovine milk constitutes an essential part of human diet, especially for children,
due to its enrichment of various nutrients. We recently developed an effective protocol for the …

[HTML][HTML] Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells

SK Sze, DPV de Kleijn, RC Lai, EKW Tan… - Molecular & Cellular …, 2007 - ASBMB
Transplantation of mesenchymal stem cells (MSCs) has been used to treat a wide range of
diseases, and the mechanism of action is postulated to be mediated by either differentiation …

Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery

GD Webb, LH Lim, VMS Oh, SB Yeo, YP Cheong… - … of Pharmacology and …, 2008 - ASPET
This study aimed to test these hypotheses: cystathionine γ-lyase (CSE) is expressed in a
human artery, it generates hydrogen sulfide (H2S), and H2S relaxes a human artery. H2S is …

A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy

B Hou, L Yi, D Hu, Z Luo, D Gao, C Li, B Xing… - Nature Biomedical …, 2023 - nature.com
Monitoring X-ray radiation in the gastrointestinal tract can enhance the precision of
radiotherapy in patients with gastrointestinal cancer. Here we report the design and …