Transforming growth factor-β1 (TGF-β1) is a polypeptide member of the transforming growth
factor β superfamily of cytokines. It is a secreted protein that performs many cellular functions …

The adoption of the Western-style diet, with decreased fish intake and lack of exercise, has
increased the prevalence of cardiovascular disease (CVD) in Japan. Statin treatment has …

The obesity epidemic is a global public health concern that increases the likelihood of
morbidity and mortality of metabolic and cardiovascular disease (CVD) and threatens to …

Endothelial senescence is thought to play a role in cardiovascular diseases such as
atherosclerosis. We hypothesized that endothelial microRNAs (miRNAs) regulate …

Eight years have passed since the publication of the only guideline on cardiac rehabilitation
(CR) in Japan,“Guidelines for rehabilitation in patients with cardiovascular disease (JCS …

Obesity stimulates chronic inflammation in adipose tissue, which is associated with insulin
resistance, although the underlying mechanism remains largely unknown. Here we showed …

Abstract Objective Activated factor X (FXa) plays a key role in the coagulation cascade,
whereas accumulating evidence suggests that it also contributes to the pathophysiology of …

Background It is unknown whether canagliflozin, a selective sodium glucose co-transporter
2 inhibitor, reduces epicardial adipose tissue (EAT) thickness, which is associated with …

MicroRNAs (MiRNAs) are short, non-coding RNA that regulate a variety of cellular functions
by suppressing target protein expression. We hypothesized that a set of microRNA regulate …

Androgen has anabolic effects on cardiac myocytes and has been shown to enhance left
ventricular enlargement and function. However, the physiological and patho-physiological …