Endothelial nitric oxide synthase–independent protective action of statin against angiotensin II–induced atrial remodeling via reduced oxidant injury
S Yagi, M Akaike, K Aihara, K Ishikawa, T Iwase… - …, 2010 - Am Heart Assoc
Activation of the renin-angiotensin system exacerbates atrial remodeling, leading to atrial
fibrillation and thrombosis, especially in a condition with decreased NO bioavailability …
fibrillation and thrombosis, especially in a condition with decreased NO bioavailability …
Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia
S Yagi, M Akaike, K Aihara, T Iwase… - … of atherosclerosis and …, 2010 - jstage.jst.go.jp
Aim: Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, has been shown to reduce
the intestinal absorption of cholesterol. We investigated whether it also has beneficial effects …
the intestinal absorption of cholesterol. We investigated whether it also has beneficial effects …
Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor …
S Yoshida, K Aihara, Y Ikeda, Y Sumitomo-Ueda… - Circulation, 2013 - Am Heart Assoc
Background—Hypoandrogenemia is associated with an increased risk of ischemic
diseases. Because actions of androgens are exerted through androgen receptor (AR) …
diseases. Because actions of androgens are exerted through androgen receptor (AR) …
Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function
S Yoshida, K Aihara, H Azuma, R Uemoto… - Atherosclerosis, 2010 - Elsevier
BACKGROUND: Dehydroepiandrosterone sulfate (DHEAS) is thought to be associated with
life expectancy and anti-aging. However, its biological significance in atherosclerosis …
life expectancy and anti-aging. However, its biological significance in atherosclerosis …
[HTML][HTML] High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension
S Yagi, M Akaike, K Aihara, T Iwase, S Yoshida… - Hypertension …, 2011 - nature.com
Cognitive impairment leading to dementia is associated with high prevalence of
hypertension, decreased quality of life and poor prognosis. Aldosterone is known as a risk …
hypertension, decreased quality of life and poor prognosis. Aldosterone is known as a risk …
Heparin cofactor II protects against angiotensin II-induced cardiac remodeling via attenuation of oxidative stress in mice
Y Sumitomo-Ueda, K Aihara, T Ise, S Yoshida… - …, 2010 - Am Heart Assoc
Heparin cofactor II (HCII), a serine protease inhibitor, inhibits tissue thrombin action after
binding with dermatan sulfate proteoglycans in the extracellular matrix of the vascular …
binding with dermatan sulfate proteoglycans in the extracellular matrix of the vascular …
Activation of peroxisome proliferator-activated receptor α in megakaryocytes reduces platelet-derived growth factor-BB in platelets
S Hashizume, M Akaike, H Azuma… - … of Atherosclerosis and …, 2011 - jstage.jst.go.jp
Aim: Platelet-derived growth factor (PDGF)-BB plays a crucial role in atherosclerosis and
vascular remodeling by promoting the migration and proliferation of vascular smooth muscle …
vascular remodeling by promoting the migration and proliferation of vascular smooth muscle …
Effect of low-dose (1 mg/day) pitavastatin on left ventricular diastolic function and albuminuria in patients with hyperlipidemia
S Yagi, M Akaike, KI Aihara, T Iwase, K Ishikawa… - The American journal of …, 2011 - Elsevier
The aim of the present study was to evaluate the factors that modulate the protective action
of statins on cardiorenal function, regardless of the lipid-lowering effect. To treat abnormal …
of statins on cardiorenal function, regardless of the lipid-lowering effect. To treat abnormal …
Bosentan ameliorated exercise-induced pulmonary arterial hypertension complicated with systemic sclerosis
S Yagi, M Akaike, T Iwase, K Kusunose, T Niki… - Internal …, 2010 - jstage.jst.go.jp
Pulmonary arterial hypertension (PAH) is a frequent complication in patients with systemic
sclerosis. Bosentan is used in patients with symptomatic PAH; however, it has not been …
sclerosis. Bosentan is used in patients with symptomatic PAH; however, it has not been …
[HTML][HTML] Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors
T Ise, K Aihara, Y Sumitomo-Ueda, S Yoshida… - Hypertension …, 2011 - nature.com
Thrombin has a crucial role in cardiac remodeling through protease-activated receptor-1
activation in cardiac fibroblasts and cardiomyocytes. As heparin cofactor II (HCII) inhibits the …
activation in cardiac fibroblasts and cardiomyocytes. As heparin cofactor II (HCII) inhibits the …