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Cardiac events occurred commonly among apparently healthy Filipinos with the Brugada ECG pattern in the LIFECARE cohort
  1. Giselle G Gervacio1,
  2. Jaime Alfonso Manalo Aherrera1,
  3. Rody G Sy1,
  4. Lauro L Abrahan IV1,
  5. Michael Joseph Agbayani1,
  6. Felix Eduardo Punzalan1,
  7. Elmer Jasper B Llanes1,
  8. Paul Ferdinand M Reganit1,
  9. Olivia T Sison2,
  10. E Shyong Tai3,
  11. Felicidad V Velandria2,
  12. Allan Gumatay4,
  13. Nina T Castillo-Carandang2
  1. 1 Department of Medicine, University of the Philippines-Philippine General Hospital, Manila, Philippines
  2. 2 Department of Clinical Epidemiology, University of the Philippines, Manila, Philippines
  3. 3 Saw Swee Hock School of Public Health and Department of Medicine Yong Loo Lin School of Medicine, National University Health Care System Singapore, Singapore
  4. 4 Manila Doctors Hospital, Manila, Philippines
  1. Correspondence to Dr Giselle G Gervacio, Department of Medicine, University of the Philippines-Philippine General Hospital, Manila 1000, Philippines; giselle_gervacio{at}


Background Brugada syndrome is the mechanism for sudden unexplained death. The Brugada ECG pattern is found in 2% of Filipinos. There is a knowledge gap on the clinical outcome of these individuals. The clinical profile and 5-year cardiac event rate of individuals with the Brugada ECG pattern were determined in this cohort.

Methods This is a sub-study of LIFECARE (Life Course Study in Cardiovascular Disease Epidemiology), a community based cohort enrolling healthy individuals 20 to 50 years old conducted in 2009–2010. ECGs of all enrollees were screened independently by three cardiologists. The prevalence of the coved Brugada ECG pattern was ascertained, and the 5-year cardiac event rate was determined among those individuals with this pattern. The participants were contacted to determine the occurrence of cardiac events, which included syncope, presyncope, seizures, cardiac arrest and unexplained vehicular accidents.

Results A total of 3072 ECGs were reviewed, and 14 subjects (0.4%) with the coved Brugada ECG pattern were identified. Four had a cardiac event on follow-up at 5 years, but all remained alive. Most of these 14 coved Brugada individuals were healthy and asymptomatic at baseline.

Conclusion Cardiac events occurred commonly among initially asymptomatic Filipinos with the coved Brugada ECG pattern. Such patients need to be followed up closely.

  • brugada
  • sudden cardiac death
  • sudden adult death syndrome

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  • Contributors All authors contributed to the planning, conduct, and reporting of the work.

  • Funding Main funding for the substudy was covered by a grant from the Philippine College of Physicians. The following organiSations provided financial assistance to the project: Pfizer Asia, Pfizer International, Pfizer Philippines, Department of Health (Philippines), Philippine Council for Health and Research Development, Diabetes Philippines, Philippine Society of Hypertension, and the Philippine Lipid and Atherosclerosis Society. The University of the Philippines Manila (through the College of Medicine) and the National Institutes of Health’s Institute of Clinical Epidemiology have also supported the project.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval The protocol was submitted to the University of the Philippines Medical Research Ethics Board (UPMREB) for ethics review and approval, which conforms to the provisions of the Declaration of Helsinki. The study was approved on 12 August 2015 with a UPMREB Code (MED) 2015-310-01. The study was conducted upon approval from the UPMREB. Informed consent was taken by a research assistant during his/her personal visit from all the participants. To ensure confidentiality, the identities of patients were assigned to a number code. No other information was obtained aside from what is stated in the protocol.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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