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DKA-induced Brugada phenocopy mimicking STEMI
  1. Christian Abrahim1,
  2. Satish Maharaj2
  1. 1 Department of Internal Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA
  2. 2 Department of Internal Medicine, University of Florida, Jacksonville, Florida, USA
  1. Correspondence to Dr Satish Maharaj, Department of Internal Medicine, University of Florida, Jacksonville, FL 32209, USA; satish.maharaj{at}jax.ufl.edu

Abstract

Case presentation A 47-year-old Caucasian woman with type 1 diabetes presented with epigastric pain and vomiting. She had not been adherent with her diet and insulin therapy for the past 3 weeks. She never had a personal or family history of arrhythmia-related symptoms, ventricular tachycardia or fibrillation (VT/VF) or premature sudden cardiac death (SCD). Examination revealed dry mucosa, tachycardia and epigastric tenderness to palpation. Her ECG showed ST elevations (V1–V3) with associated T wave inversions (figure 1A). A baseline ECG 1 year ago had no abnormalities. Serial troponin I and T were negative, but Creatinine Kinase MB (CKMB) was elevated. Her biochemistry test showed sodium of 118 mM, potassium of 6.7 mM, bicarbonate of 4 mM, anion gap of 40, glucose of 985 mM and beta hydroxyl-butyrate of >45.0 mg/dL. Cardiac catheterisation revealed normal anatomy with all vessels widely patent; left ventricular end diastolic pressure (LVEDP) was 1 mm Hg. With treatment, diabetic ketoacidosis (DKA) resolved after 8 hours and repeat ECG showed all changes had resolved (figure 1B). She was monitored on telemetry without any VT/VF episodes. Serial ECGs were done with resolution of changes. She had no positive studies for inducible VT. The rest of her admission was uneventful.

Figure 1

(A) ECG on presentation. (B) ECG 8 hours after admission.

Question Which of the following is the best next step in managing this patient?

  1. Quinidine therapy.

  2. Implantable cardioverter-defibrillator (ICD) placement.

  3. SCN5A gene mutation testing.

  4. Observation without therapy.

  • brugada
  • electrocardiography
  • stemi
  • diabetic heart disease

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Footnotes

  • Contributors The manuscript has been read and approved by both authors. Both were responsible for concept/design. Both authors contributed to drafting, critical revision of the article and approval of the article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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