Clinical introduction A 25-year-old woman with a diagnosis of hypertrophic cardiomyopathy (HCM) and pre-excitation on ECG presented with unexplained syncope and daily palpitation. Genetic testing was positive for lysosome-associated membrane protein 2 (LAMP2) mutation which confirmed the diagnosis of Danon disease. Her younger sister was diagnosed with a similar condition and received a defibrillator implantation. Her 12-lead ECG (figure 1) and a long strip tracing (figure 2) are shown below.
Question Where is the location of the accessory pathway and what is the next appropriate management?
Anteroseptal pathway and catheter ablation
Mid-septal pathway and pacemaker/defibrillator implantation
Right lateral pathway and catheter ablation
Fasciculoventricular pathway and electrophysiological study
Left lateral pathway and electrophysiological study
- sudden cardiac death
- WPW syndrome
- cardiomyopathy hypertrophic
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Contributors KA and VK wrote and revised the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.
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