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Transmitral inflow wave and progression from paroxysmal to permanent atrial fibrillation in Asian people
  1. Takashi Nakagawa1,2,
  2. Hisao Hara1,
  3. Masaya Yamamoto1,
  4. Yumi Matsushita3,
  5. Yukio Hiroi1
  1. 1Department of Cardiology, National Center for Global Health and Medicine, Tokyo, Japan
  2. 2Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
  3. 3Department of Clinical Research, National Center for Global Health and Medicine, Tokyo, Japan
  1. Correspondence to Dr Takashi Nakagawa, Cardiology, National Center for Global Health and Medicine, Tokyo 162-8655, Japan; tnakagawa{at}


Objective Paroxysmal atrial fibrillation could progress to permanent atrial fibrillation. Whether the transmitral inflow waves could be used to predict progression from paroxysmal atrial fibrillation to permanent atrial fibrillation is unknown. Therefore, we investigated the association between the transmitral inflow waves and progression of paroxysmal atrial fibrillation.

Method We performed a retrospective study by analysing clinical and echocardiographic data from 88 patients with paroxysmal atrial fibrillation. We excluded patients who had structural heart disease, significant valvular disease, cardiomyopathy, cardiac device implantation or a left ventricular ejection fraction <50%.

Result The patients with progression to permanent atrial fibrillation were more likely to be male and had lower peak A velocity than those without progression. After adjusting for covariates, lower peak A velocity remained the independent predictor of progression to permanent atrial fibrillation (p=0.025).

Conclusion The A velocity could be useful for predicting progression to permanent atrial fibrillation in Asian people.

  • paroxysmal atrial fibrillation
  • progression
  • echocardiography
  • transmitral inflow wave
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  • Contributors TN designed the study and wrote the initial draft of the manuscript. HH and YM contributed to analysis and interpretation of data and assisted in the preparation of the manuscript. All other authors have contributed to interpretation of data, critically reviewed the manuscript, approved the final version of the manuscript and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The study protocol was approved by the institutional ethics committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No data are available.

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