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Depression in patients with hypertrophic cardiomyopathy: is there any relation with the risk factors for sudden death?
  1. Artemis Igoumenou1,
  2. Giorgos Alevizopoulos2,
  3. Aris Anastasakis3,
  4. Errika Stavrakaki4,
  5. Pavlos Toutouzas3,
  6. Christodoulos Stefanadis3
  1. 1Oxford Health NHS Foundation Trust, Oxford, UK
  2. 2Department of Mental Health and Behavioural Sciences, University of Athens, Greece
  3. 3Division of Inherited Cardiovascular Disease, Department of Cardiology, University of Athens, Athens, Greece
  4. 4Ministry of Health, Greece
  1. Correspondence to Dr Artemis Igoumenou, Rectory Centre, Rectory Road, Oxford OX4 1DU, UK; igoumenouartemis{at}


Objectives The aim of this study was to investigate whether depressive symptoms are related to the risk factors for sudden death in patients with hypertrophic cardiomyopathy (HCM).

Design 121 patients diagnosed as having HCM were assessed for depressive symptomatology using the Beck Depression Inventory and the Center for Epidemiological Studies Depression Scale (CES-D) and followed up for a period of 2 years. For the interview, the authors used the Structured Clinical Interview for DSM-III/DSM-III-R. A multidimensional longitudinal study was carried out with both somatic and psychological symptoms and signs taken into consideration. SPSS was used for the statistical analysis.

Results (1) Patients with HCM are more depressed than the general population. (2) There is no positive correlation between the occurrence of depressive symptoms and the risk factors for sudden death in patients with HCM. (3) Patients at high risk for sudden death are not more depressed than the others. (4) Time from diagnosis of the cardiac disease is not related to the presence and severity of depressive symptoms.

Conclusions Patients with HCM are more depressed than the general population. The authors suggest that depressive symptoms and risk factors for sudden death in these patients are not related. It is important to screen for mood disorders in this patient population in order to provide an early diagnosis and treatment of the psychiatric disease.

  • Hypertrophic cardiomyopathy
  • sudden death
  • depression
  • psychology/psychiatry
  • anxiety
  • depression
  • risk factors
  • cardiomyopathy hypertrophic

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  • Competing interests None.

  • Ethics approval Ethics approval was provided by National and Kapodistrian University of Athens.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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