Article Text

Interferon-α and pericardial injury: a case report and literature review
  1. Fayaz A Hakim1,
  2. Sujata Singh3,
  3. Anil Pandit1,
  4. Jorge R Alegria1,
  5. John Camoriano2,
  6. Melissa L Stanton4,
  7. Farouk Mookadam1
  1. 1Department of Cardiovascular Diseases, Scottsdale, Arizona, USA
  2. 2Hematology-Oncology, Scottsdale, Arizona, USA
  3. 3Internal Medicine, Scottsdale, Arizona, USA
  4. 4Laboratory Medicine and pathology, Mayo Clinic, Scottsdale, Arizona, USA
  1. Correspondence to Dr Farouk Mookadam, Mayo Clinic College of Medicine, 13400 E Shea Blvd, Scottsdale, AZ 85255, USA; mookadam.farouk{at}


Interferon- α (IFN-α) alone or in combination with other chemotherapeutic agents has been used in the management of many malignant and non-malignant conditions. Pericarditis with or without pericardial effusion has been reported with IFN-α therapy, and available literature is limited to case reports. Pericardial constriction after interferon use has not been described in the published literature to date. We performed a systematic review of literature to address the demographic features, clinical presentation, diagnosis, treatment and outcome of interferon-related pericardial injury.

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