@article {Pattoneri91, author = {Paolo Pattoneri and Giovanna Pel{\`a} and Enrico Montanari and Ilaria Pesci and Paolo Moruzzi and Alberto Montanari}, title = {Usefulness of myocardial performance index in multiple sclerosis mitoxantrone-induced cardiotoxicity}, volume = {4}, number = {1}, pages = {91--94}, year = {2012}, doi = {10.1136/heartasia-2012-010117}, publisher = {British Medical Journal Publishing Group}, abstract = {Aims The authors sought to investigate the ability of the Doppler-derived myocardial performance index (MPI) to predict cardiotoxicity in multiple sclerosis (MS) patients under mitoxantrone therapy.Methods and results The aauthors prospectively evaluated 28 MS patients (mean age 41{\textpm}9 years, 12 males and 16 females) treated with low-dose mitoxantrone (basal mean cumulative dose 30{\textpm}14 mg/m2, end of follow-up mean dose 41{\textpm}17 mg/m2). All patients underwent two-dimensional and Doppler-echocardiography at baseline and after a mean follow-up of 22{\textpm}8 months. MPI was estimated using mitral inflow and left ventricular (LV) outflow pattern. Comparing data at baseline and at the end of follow-up, significant decrease in ejection fraction (EF) was observed (60{\textpm}5 vs 56{\textpm}4, p\<0.03). The MPI was 0.52{\textpm}0.1 at baseline and 0.60{\textpm}0.1 at the end of follow-up (p\<0.04). Such difference was mainly due to a isovolumic relaxation time prolongation (80{\textpm}12 at baseline and 98{\textpm}30 at the end of follow-up, p\<0.05). The area under the receiver operating characteristic curve, analysed for an MPI cut-point value of 0.57, in identifying a significant reduction of LVEF <=50\% was of 0.94{\textpm}0.065 with sensitivity and specificity of 97.5\% and 90\%, respectively.Conclusion In conclusion, it can be speculated that a higher basal value of MPI could represent a subclinical LV cardiotoxicity, identifying a future decrease of EF and a progression to congestive heart failure in MS patients under mitoxantrone therapy.}, URL = {https://heartasia.bmj.com/content/4/1/91}, eprint = {https://heartasia.bmj.com/content/4/1/91.full.pdf}, journal = {Heart Asia} }