PT  - JOURNAL ARTICLE
AU  - Yuri Nakajima
AU  - Osami Kawarada
AU  - Akihiro Higashimori
AU  - Yoshiaki Yokoi
AU  - Kan Zen
AU  - Hitoshi Anzai
AU  - Hideki Doi
AU  - Seiji Hokimoto
AU  - Shigenori Ito
AU  - Taku Kato
AU  - Teruyoshi Kume
AU  - Yoshiaki Shintani
AU  - Shuzou Tanimoto
AU  - Yoshinori Tsubakimoto
AU  - Makoto Utsunomiya
AU  - Kunihiro Nishimura
AU  - Satoshi Yasuda
TI  - Predictors of cardiac benefits of renal artery stenting from a multicentre retrospective registry
AID  - 10.1136/heartasia-2017-010934
DP  - 2017 Sep 01
TA  - Heart Asia
PG  - e010934
VI  - 9
IP  - 2
4099  - http://heartasia.bmj.com/content/9/2/e010934.short
4100  - http://heartasia.bmj.com/content/9/2/e010934.full
AB  - Objectives There have been limited data regarding the prediction of cardiac benefits after renal artery stenting for patients with atherosclerotic renal artery disease (ARAD). The aim of this multicentre retrospective study was to identify clinical or echocardiographic factors associated with improvements of cardiac symptoms after renal artery stenting.Methods We enrolled 58 patients with de novo ARAD undergoing successful renal artery stenting for heart failure, angina or both between January 2000 and August 2015 at 13 hospitals.Results Improvement of cardiac symptoms was observed in 86.2% of patients during a mean follow-up of 6.0±2.7 months. Responders demonstrated significantly lower New York Heart Association functional class, higher estimated glomerular filtration rate, lower serum creatinine and lower interventricular septal wall thickness (IVS), lower left ventricular mass index, lower left atrial dimension and lower E-velocity than non-responders. Backward stepwise multivariate analysis identified IVS as an independent predictor of improvement of cardiac symptoms (OR 0.451, 95% CI 0.209 to 0.976; p=0.043). According to receiver operating characteristic curve analysis, an IVS cut-off of 11.9 mm provided the best predictive value, with sensitivity of 71.4%, specificity of 75.5% and accuracy of 73.5%. The positive predictive value was 74.5% and the negative predictive value was 72.5%.Conclusions This multicentre retrospective study shows that the echocardiographic index of IVS is an independent predictor for improvement of cardiac symptoms after renal artery stenting.