@article {Cheunge010970, author = {Angel Cheung and Mengqi Gong and Roberto Bellanti and Sadeq Ali-Hasan-Al-Saegh and Guangping Li and Eul{\`a}lia Roig and Julio N{\'u}{\~n}ez and Thomas D Stamos and Mehmet Birhan Yilmaz and Kaya Hakki and William K K Wu and Sunny Hei Wong and Wing Tak Wong and George Bazoukis and Konstantinos Lampropoulos and Lah Ah Tse and Jichao Zhao and Gregory Y H Lip and Adrian Baranchuk and Martin C S Wong and Tong Liu and Gary Tse}, editor = {,}, title = {Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis}, volume = {10}, number = {1}, elocation-id = {e010970}, year = {2018}, doi = {10.1136/heartasia-2017-010970}, publisher = {British Medical Journal Publishing Group}, abstract = {Background Cancer antigen-125 (Ca-125) is traditionally recognised as a tumour marker and its role in cardiovascular diseases has been studied only in recent years. Whether Ca-125 is elevated in patients with atrial fibrillation (AF) and its levels predict the risk of AF remains controversial. Therefore, we conducted a systematic review and meta-analysis of the association between Ca-125 levels and AF.Methods PubMed and EMBASE databases were searched until 1 June 2017 for studies that evaluated the association between Ca-125 and AF. Inclusion criteria included studies that compare Ca-125 in patients with and without AF, or those reporting HRs/ORs for risk of AF stratified by Ca-125 levels.Results A total of 39 entries were retrieved from the databases, of which 10 studies were included in the final meta-analysis. Ca-125 was significantly higher in patients with AF compared with those in sinus rhythm (mean difference=16 U/mL, 95\% CI 2 to 30 U/mL, P\<0.05; I2: 98\%). Ca-125 significantly increased the risk of AF (HR: 1.39, 95\% CI 1.06 to 1.82, P\<0.05; I2: 84\%).Conclusion Ca-125 was significantly higher in patients with AF than in those in sinus rhythm, and high Ca-125 is predictive of AF occurrence. However, the high heterogeneity observed means there is an uncertainty in the relationship between Ca-125 and AF, which needs to be confirmed by larger prospective studies.}, URL = {https://heartasia.bmj.com/content/10/1/e010970}, eprint = {https://heartasia.bmj.com/content/10/1/e010970.full.pdf}, journal = {Heart Asia} }