RT Journal Article SR Electronic T1 Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis JF Heart Asia FD BMJ Publishing Group Ltd, British Cardiovascular Society and Asia Pacific Heart Association SP e010970 DO 10.1136/heartasia-2017-010970 VO 10 IS 1 A1 Angel Cheung A1 Mengqi Gong A1 Roberto Bellanti A1 Sadeq Ali-Hasan-Al-Saegh A1 Guangping Li A1 Eulàlia Roig A1 Julio Núñez A1 Thomas D Stamos A1 Mehmet Birhan Yilmaz A1 Kaya Hakki A1 William K K Wu A1 Sunny Hei Wong A1 Wing Tak Wong A1 George Bazoukis A1 Konstantinos Lampropoulos A1 Lah Ah Tse A1 Jichao Zhao A1 Gregory Y H Lip A1 Adrian Baranchuk A1 Martin C S Wong A1 Tong Liu A1 Gary Tse A1 , YR 2018 UL http://heartasia.bmj.com/content/10/1/e010970.abstract AB Background Cancer antigen-125 (Ca-125) is traditionally recognised as a tumour marker and its role in cardiovascular diseases has been studied only in recent years. Whether Ca-125 is elevated in patients with atrial fibrillation (AF) and its levels predict the risk of AF remains controversial. Therefore, we conducted a systematic review and meta-analysis of the association between Ca-125 levels and AF.Methods PubMed and EMBASE databases were searched until 1 June 2017 for studies that evaluated the association between Ca-125 and AF. Inclusion criteria included studies that compare Ca-125 in patients with and without AF, or those reporting HRs/ORs for risk of AF stratified by Ca-125 levels.Results A total of 39 entries were retrieved from the databases, of which 10 studies were included in the final meta-analysis. Ca-125 was significantly higher in patients with AF compared with those in sinus rhythm (mean difference=16 U/mL, 95% CI 2 to 30 U/mL, P<0.05; I2: 98%). Ca-125 significantly increased the risk of AF (HR: 1.39, 95% CI 1.06 to 1.82, P<0.05; I2: 84%).Conclusion Ca-125 was significantly higher in patients with AF than in those in sinus rhythm, and high Ca-125 is predictive of AF occurrence. However, the high heterogeneity observed means there is an uncertainty in the relationship between Ca-125 and AF, which needs to be confirmed by larger prospective studies.