HRs (95% CI) from Cox regression for MACE, death, and death and heart failure, associated with Log aldosterone and upper quartiles compared to the lowest quartile of these variables, in post-acute myocardial infarction patients (N=955)
| Univariate | Multivariate | p Values (adjusted) | |
|---|---|---|---|
| MACE | |||
| Log aldosterone | 1.39 (1.13 to 1.72) | 1.26 (1.01 to 1.56) | 0.041 |
| First quartile | Reference | Reference | |
| Second quartile | 1.42 (0.99 to 2.05) | 1.28 (0.87 to 1.87) | 0.210 |
| Third quartile | 1.39 (0.96 to 2.01) | 1.23 (0.81 to 1.83) | 0.343 |
| Fourth quartile | 1.75 (1.23 to 2.51) | 1.46 (1.01 to 2.12) | 0.043 |
| All-cause mortality | |||
| Log aldosterone | 1.82 (1.32 to 2.50) | 1.60 (1.13 to 2.27) | 0.008 |
| First quartile | Reference | Reference | |
| Second quartile | 1.60 (0.86 to 2.99) | 1.30 (0.68 to 2.50) | 0.425 |
| Third quartile | 2.17 (1.20 to 3.95) | 1.45 (0.75 to 2.79) | 0.273 |
| Fourth quartile | 2.72 (1.5 to 4.86) | 2.21 (1.21 to 4.03) | 0.010 |
| All-cause mortalilty and hospitalisation for heart failure | |||
| Log aldosterone | 1.66 (1.29 to 2.15) | 1.50 (1.14 to 1.97) | 0.003 |
| First quartile | Reference | Reference | |
| Second quartile | 1.40 (0.86 to 2.27) | 1.34 (0.80 to 2.25) | 0.272 |
| Third quartile | 1.87 (1.17 to 2.97) | 1.64 (0.97 to 2.78) | 0.064 |
| Fourth quartile | 2.46 (1.56 to 3.85) | 2.06 (1.29 to 3.28) | 0.002 |
Multivariate HRs were adjusted for age, sex, history of diabetes, hypertension, smoking, Killip class or heart failure, eGFR, NTproBNPd, and ACE inhibitors or angiotensin receptor blockers, β blockers, statins, and diuretics.
eGFR, estimated glomerular filtration rate; MACE, major adverse cardiovascular events.