Table displaying the frequency and duration of arrhythmias (in seconds) between uraemic (SNx, n=10) and non-uraemic (Sham SNx, n=10) animals undergoing one cycle of IPC followed by myocardial ischaemia-reperfusion
| Sham SNx+IPC | SNx+IPC | p Value | |
|---|---|---|---|
| Duration of preconditioning ischaemic arrhythmias | 15 (4–30) | 6 (4–15) | 0.23 |
| Duration of preconditioning reperfusion arrhythmias | 60 (44–79) | 36 (25–45) | 0.02 |
| Duration of i35 ischaemic arrhythmias | 8 (2–18) | 6 (0–16) | 0.74 |
| Duration post i35 reperfusion arrhythmias | 0 (0–10) | 0 (0–6) | 0.64 |
| Total duration of ischaemic arrhythmias | 30 (10–43) | 16 (8–24) | 0.22 |
| Total duration of reperfusion arrhythmias | 62 (44–88) | 38 (29–47) | 0.01 |
| Total duration of all arrhythmias including preconditioning | 81 (68–144) | 56 (41–69) | 0.02 |
| Number of arrhythmias occurring during preconditioning | 3 (2–4) | 2 (1–3) | 0.37 |
| Number of i25 ischaemic arrhythmias | 2 (1–3) | 1 (0–1) | 0.32 |
| Number of post i25 reperfusion arrhythmias | 1 (0–1) | 0 (0–1) | 0.18 |
| Total number of all arrhythmias | 6 (3–7) | 4 (3–6) | 0.27 |
i25 refers to the 25-min period of lethal ischaemia and i35 refers to the 35-min period of lethal ischaemia. Arrhythmias were defined as a haemodynamic disturbance in the mean arterial pressure (MAP) trace waveform lasting longer than 2 s and occurring during each phase of the experimental protocol, with data displayed as median (IQR). Data displayed as median (IQR), with p value calculated using Mann-Whitney test.
IPC, ischaemic preconditioning; SNx, subtotal nephrectomy.