American Heart Association antibiotic regimens for IE prophylaxis before dental procedures, 1955–2007
| Year* | Primary regimens for dental procedures† |
|---|---|
| 19556 | Aqueous penicillin 600 000 U and procaine penicillin 600 000 U in oil containing 2% aluminium monostearate administered intramuscularly 30 min before the operative procedure. |
| 19577 | For 2 days before surgery, penicillin 200 000–250 000 U by mouth four times per day. On day of surgery, penicillin 200 000–250 000 U by mouth four times per day and aqueous penicillin 600 000 U with procaine penicillin 600 000 U intramuscularly 30–60 min before surgery. For 2 days after, 200 000–250 000 U by mouth four times per day. |
| 19608 | Step I: prophylaxis 2 days before surgery with procaine penicillin 600 000 U intramuscularly on each day. |
| Step II: day of surgery––procaine penicillin 600 000 U intramuscularly supplemented by crystalline penicillin 600 000 U intramuscularly 1 hour before surgical procedure. | |
| Step III: for 2 days after surgery––procaine penicillin 600 000 U intramuscularly each day. | |
| 19659 | Day of procedure: procaine penicillin 600 000 U, supplemented by crystalline penicillin 600 000 U intramuscularly 1–2 hours before the procedure. |
| For 2 days after procedure: procaine penicillin 600 000 U intramuscularly each day. | |
| 197210 | Procaine penicillin G 600 000 U mixed with crystalline penicillin G 200 000 U intramuscularly 1 hour before procedure and once daily for the 2 days after the procedure. |
| 197711 | Aqueous crystalline penicillin G (1 000 000 U intramuscularly) mixed with procaine penicillin G (600 000 U intramuscularly) 30 min to 1 hour before procedure and then penicillin V 500 mg orally every 6 hours for eight doses. |
| 198412 | Penicillin V 2 g orally 1 hour before; then, 1 g 6 hours after initial dose |
| 199013 | Amoxicillin 3 g orally 1 hour before procedure; then, 1.5 g 6 hours after initial dose |
| 199714 | Amoxicillin 2 g orally 1 hour before procedure |
| 200715 | Amoxicillin 2 g orally 30 min to 1 hour before procedure |
*Reference number follows year.
†Regimens listed are for adults and represented the initial regimen listed in each version of the recommendations.
IE, infective endocarditis.