Analytical characteristics of high-sensitivity cardiac troponin assays6 8 9
| Cardiac troponin concentrations (ng/L) at: | ||||
|---|---|---|---|---|
| Assay (manufacturer) | Lower limit of detection | 99th percentile (CV†) | 10% CV | Measurable values* (% subjects) |
| Troponin T | ||||
| Elecsys (Roche) | 5.0 | 14 (8%) | 13 | NA |
| Troponin I | ||||
| Access (Beckman) | 2–3 | 8.6 (10%) | 8.6 | 80 |
| ARCHITECT (Abbott)‡ | 1.5 | 25.6 (<5%) | 6.0 | 92.3 |
| Erenna (Singulex) | 0.09 | 10.1 (9%) | 0.88 | 100 |
| MTP (Nanosphere) | 0.2 | 2.8 (9.5%) | 0.5 | NA |
| Vista (Siemens) | 0.5 | 9 (5%) | 3 | 86 |
Adapted from Apple et al.6 Reproduced with permission from the American Association for Clinical Chemistry.
*Proportion of subjects with levels above the lower limit of detection.
†CV at 99th percentile.
‡Taken from Aw et al.9
CV, coefficient of variation; MTP, microtiter plate.