D:A:D score corresponding to 50% cumulative CVD risk (D50) (%) | Per cent reduction from actual data D50 scores (%) | |
Actual data | 2.19 | – |
Low HDL raised to 1 mmol/L | 2.05 | 6 |
High total cholesterol reduced to 5.2 mmol/L | 2.03 | 7 |
Low CD4 counts raised to 500 cells/µL | 1.90 | 13 |
High systolic blood pressure lowered to 130 mm Hg | 1.90 | 13 |
Smoking prevention | 1.90 | 13 |
Diabetes prevention | 1.84 | 16 |
Optimal (combination of all scenarios above) | 1.23 | 44 |
D50 represents the median CVD D:A:D risk score following a per cent cumulative frequency calculation. The higher the score the more the risk of a CVD event over the next 5 years.
Percent reduction is obtained by the following method (Actual D50 data score- D50 score derived from a hypothetical scenario)/Actual data D50 score*100.
CVD, cardiovascular disease; D:A:D, Data Collection on Adverse Effects of Anti-HIV Drugs Study; HDL, high-density lipoprotein.