Spirometry | Total | HFrEF LVEF: <40 (n=70) | HFmrEF LVEF: 40–49 (n=55) | HFpEF LVEF: ≥50 (n=61) | p Value | |||
Total | HFrEF versus HFmrEF | HFmrEF versus HFpEF | HFrEF versus HFpEF | |||||
Diagnosis COPD (n=186) (n (%)) | 62 (33) | 26 (37) | 20 (36) | 16 (26) | 0.70 | >0.99 | >0.99 | >0.99 |
FEV1 (L) (n=184) | 2.3±0.7 | 2.4±0.7 | 2.4±0.8 | 2.3±0.7 | 0.68 | >0.99 | >0.99 | >0.99 |
FVC (L) (n=184) | 3.3±0.9 | 3.4±0.9 | 3.4±0.9 | 3.1±1.0 | 0.14 | >0.99 | 0.17 | 0.41 |
FEV1/FVC (%) (n=184) | 71.2±11.7 | 70.2±11.9 | 69.7±13.2 | 73.8±9.7 | 0.12 | >0.99 | 0.20 | 0.27 |
FEV1 % pred (n=175) | 91.3±21.2 | 82.1±20.5 | 86.3±19.8 | 94.0±21.8 | 0.01* | 0.81 | 0.15 | <0.01* |
DLCO (mmol/min/kPa) (n=174) | 5.6±1.7 | 5.7±1.6 | 5.7±1.8 | 5.6±1.6 | 0.95 | >0.99 | >0.99 | >0.99 |
DLCO % pred (n=174) | 69.1±16.0 | 67.6±14.4 | 67.9±19.1 | 72.5±15.4 | 0.20 | >0.99 | 0.42 | 0.30 |
Abnormal DLCO (n=141) (n (%)) | 77 (55) | 29 (59) | 26 (55) | 22 (49) | 0.60 | >0.99 | >0.99 | 0.96 |
Abnormal DLCO in pts without AL (n=77) | 39 (51) | 14 (58) | 12 (48) | 13 (46) | 0.66 | 0.47 | 0.91 | 0.39 |
DLCO % pred in pts with AL (n=61) | 63.5±16.1 | 65.5±14.2 | 56.8±19.7 | 68.8±11.2 | 0.06 | 0.20 | 0.07 | >0.99 |
DLCO % pred in pts without AL (n=98) | 74.2±15.3 | 70.7±13.8 | 75.9±16.3 | 76.3±15.6 | 0.24 | 0.54 | >0.99 | 0.38 |
Mean (±SD).
Median (IQR).
p Values below 0.05 in bold and with asterisks.
COPD, chronic obstructive pulmonary disease; DLCO, diffusing lung capacity for carbon monoxide; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; HF, heart failure; HFmrEF, heart failure midrange ejection fraction; HFpEF, heart failure preserved ejection fraction; HFrEF, heart failure reduced ejection fraction; pred, predicted.