Table 3

Baseline clinical and demographic characteristics of patients with and without prior ICD therapy

CharacteristicPatients with prior ICD therapy (n=18)Patients without prior ICD therapy (n=43)p value
Mean age at implantation59.9±9.357.5±12.10.42
Mean age at replacement66.1±9.563.2±130.29
Gender (%)
 Male17 (94.4)33 (76.7)<0.01
 Female1 (5.6)10 (23.3)
Type of device (%)
 ICD13 (72.2)26 (60.5)0.05
 CRT-D5 (27.8)17 (39.5)
Cardiomyopathy (%)
 ICM7 (38.9)12 (27.9)0.81
 NICM11 (61.1)27 (62.8)
 Other causes04 (9.3)
 Mean LVEF at implant (%)25.6±5.824.6±5.00.39
 Mean LVEF at replacement (%)27.6±8.332±11.90.13
 Mean eGFR at implant61.8±9.162.1±14.20.12
 Mean eGFR at replacement58.8±18.266.4±19.30.19
Medications at initial implant
 Diuretics (%)15 (83.3)22 (51.2)<0.01
 ACE inhibitor/ARB (%)18 (100)38 (88.4)0.02
 Beta-blocker (%)14 (77.8)37 (86)0.01
 Amiodarone (%)3 (16.7)5 (11.6)0.29
Medications at replacement
 Diuretics (%)13 (72.2)24 (55.8)<0.01
 ACE inhibitor/ARB (%)17 (94.4)38 (88.4)0.14
 Βeta-blockers (%)15 (83.3)40 (93)0.03
 Sotalol (%)1 (5.6)1 (2.3)0.32
 Amiodarone (%)9 (50)4 (9.3)<0.01
 ICD therapy after replacement (%)10 (55.6)3 (7)<0.01
 ATP103<0.01
 ICD shocks71<0.01
Inappropriate ICD therapy after replacement (%)01 (2.3)0.19
Number of death after replacement (%)1 (5.6)4 (9.3)0.33
  • ARB, angiotensin receptor blocker; ATP, antitachycardia pacing; CRT-D, cardiac resynchronisation therapy-defibrillator; ICD, implantable cardioverter-defibrillator; ICM, ischaemic cardiomyopathy; LVEF, left ventricular ejection fraction; NICM, non-ischaemic cardiomyopathy; eGFR, estimated glomerular filtration rate.