Characteristic | Patients with prior ICD therapy (n=18) | Patients without prior ICD therapy (n=43) | p value |
Mean age at implantation | 59.9±9.3 | 57.5±12.1 | 0.42 |
Mean age at replacement | 66.1±9.5 | 63.2±13 | 0.29 |
Gender (%) | |||
Male | 17 (94.4) | 33 (76.7) | <0.01 |
Female | 1 (5.6) | 10 (23.3) | |
Type of device (%) | |||
ICD | 13 (72.2) | 26 (60.5) | 0.05 |
CRT-D | 5 (27.8) | 17 (39.5) | |
Cardiomyopathy (%) | |||
ICM | 7 (38.9) | 12 (27.9) | 0.81 |
NICM | 11 (61.1) | 27 (62.8) | |
Other causes | 0 | 4 (9.3) | |
Mean LVEF at implant (%) | 25.6±5.8 | 24.6±5.0 | 0.39 |
Mean LVEF at replacement (%) | 27.6±8.3 | 32±11.9 | 0.13 |
Mean eGFR at implant | 61.8±9.1 | 62.1±14.2 | 0.12 |
Mean eGFR at replacement | 58.8±18.2 | 66.4±19.3 | 0.19 |
Medications at initial implant | |||
Diuretics (%) | 15 (83.3) | 22 (51.2) | <0.01 |
ACE inhibitor/ARB (%) | 18 (100) | 38 (88.4) | 0.02 |
Beta-blocker (%) | 14 (77.8) | 37 (86) | 0.01 |
Amiodarone (%) | 3 (16.7) | 5 (11.6) | 0.29 |
Medications at replacement | |||
Diuretics (%) | 13 (72.2) | 24 (55.8) | <0.01 |
ACE inhibitor/ARB (%) | 17 (94.4) | 38 (88.4) | 0.14 |
Βeta-blockers (%) | 15 (83.3) | 40 (93) | 0.03 |
Sotalol (%) | 1 (5.6) | 1 (2.3) | 0.32 |
Amiodarone (%) | 9 (50) | 4 (9.3) | <0.01 |
ICD therapy after replacement (%) | 10 (55.6) | 3 (7) | <0.01 |
ATP | 10 | 3 | <0.01 |
ICD shocks | 7 | 1 | <0.01 |
Inappropriate ICD therapy after replacement (%) | 0 | 1 (2.3) | 0.19 |
Number of death after replacement (%) | 1 (5.6) | 4 (9.3) | 0.33 |
ARB, angiotensin receptor blocker; ATP, antitachycardia pacing; CRT-D, cardiac resynchronisation therapy-defibrillator; ICD, implantable cardioverter-defibrillator; ICM, ischaemic cardiomyopathy; LVEF, left ventricular ejection fraction; NICM, non-ischaemic cardiomyopathy; eGFR, estimated glomerular filtration rate.