Table 1

Characteristics of patients at initial ICD/CRT-D implantation and at the time of ICD/CRT-D replacement

Initial implantation (n=61)Generator replacement (n=61)P value
Mean age58.2±11.464.1±12.1<0.01
Median age60.3 (15.8)65.9 (18.7)
Mean LVEF (%)24.8±5.231.2±11.6<0.01
Type of device
ICD
 Single chamber2222NA
 Dual chamber99
 Subcutaneous ICD (S-ICD)44
 CRT-D2626
NYHA heart failure class (%)
 Class I16 (26.2)23 (37.7)0.08
 Class II32 (52.5)33 (54.1)
 Class III13 (21.3)4 (6.6)
 Class IV01 (16)
Mean eGFR (mL/min/1.73 m2)70.3±16.765.3±19.20.02
History of atrial fibrillation (%)15 (24.6)23 (37.7)1.0
History of TIA/stroke (%)4 (6.6)6 (9.8)0.53
Neoplastic disease (%)01 (1.6)0.32
Diabetes mellitus (%)12 (19.7)16 (26.2)0.04
Hypertension (%)14 (22.9)16 (26.2)0.42
Medications use
 Diuretics (%)39 (63.9)37 (60.7)0.57
 ACE inhibitor or ARB (%)58 (95.1)55 (90.2)0.26
 Beta-blocker (%)53 (86.9)55 (90.2)0.48
Antiarrhythmic drugs
 Sotalol (%)7 (11.5)2 (3.3)0.16
 Amiodarone (%)8 (13.1)13 (21.3)0.17
  • TIA, transient ischaemic attackARB, angiotensin receptor blocker; CRT-D, cardiac resynchronisation therapy-defibrillator; ICD, implantable cardioverter-defibrillator; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; eGFR, estimated glomerular filtration rate.