Table 2

Characteristics of patients who met or did not meet the criteria for primary prevention ICD at the time of unit generator replacement

Met guideline criteria (n=41)Did not meet guideline criteria (n=20)P value
Gender (%)
 Male36 (87.8)14 (70)0.02
 Female5 (12.2)6 (30)
Type of device (%)
 ICD31 (75.6)8 (40)0.04
 CRT-D10 (24.4)12 (60)
Cardiomyopathy (%)
 ICM17 (41.5)2 (10)<0.01
 NICM21 (51.2)17 (85)
 Other causes3 (7.3)1 (5)
 Mean LVEF (%)24.7±5.444.5±9.20.01
 Mean eGFR (mL/min/1.73 m2)62.6±17.667.6±21.50.19
 Hypertension (%)12 (29.3)4 (20)0.11
 Diabetes mellitus (%)12 (29.3)4 (20)0.11
 Atrial fibrillation (%)16 (39)8 (40)0.89
 History of stroke/TIA (%)5 (12.2)1 (5)0.07
Medications use at generator replacement
 ACE inhibitor or ARB (%)35 (85.3)20 (100)<0.01
 Beta-blocker (%)35 (85.3)20 (100)<0.01
Antiarrhythmic drugs
 Amiodarone (%)9 (21.9)4 (20)0.44
 ICD therapy prior to generator replacement (%)13 (31.7)5 (25)0.27
 ICD therapy after generator replacement (%)11 (26.8)2 (10)<0.05
  • ARB, angiotensin receptor blocker; CRT-D, cardiac resynchronisation therapy-defibrillator; ICD, implantable cardioverter-defibrillator; ICM, ischaemic cardiomyopathy; LVEF, left ventricular ejection fraction; NICM, non-ischaemic cardiomyopathy; TIA, transient ischaemic attack; eGFR, estimated glomerular filtration rate.