Characteristics of patients who met or did not meet the criteria for primary prevention ICD at the time of unit generator replacement
| Met guideline criteria (n=41) | Did not meet guideline criteria (n=20) | P value | |
| Gender (%) | |||
| Male | 36 (87.8) | 14 (70) | 0.02 |
| Female | 5 (12.2) | 6 (30) | |
| Type of device (%) | |||
| ICD | 31 (75.6) | 8 (40) | 0.04 |
| CRT-D | 10 (24.4) | 12 (60) | |
| Cardiomyopathy (%) | |||
| ICM | 17 (41.5) | 2 (10) | <0.01 |
| NICM | 21 (51.2) | 17 (85) | |
| Other causes | 3 (7.3) | 1 (5) | |
| Mean LVEF (%) | 24.7±5.4 | 44.5±9.2 | 0.01 |
| Mean eGFR (mL/min/1.73 m2) | 62.6±17.6 | 67.6±21.5 | 0.19 |
| Hypertension (%) | 12 (29.3) | 4 (20) | 0.11 |
| Diabetes mellitus (%) | 12 (29.3) | 4 (20) | 0.11 |
| Atrial fibrillation (%) | 16 (39) | 8 (40) | 0.89 |
| History of stroke/TIA (%) | 5 (12.2) | 1 (5) | 0.07 |
| Medications use at generator replacement | |||
| ACE inhibitor or ARB (%) | 35 (85.3) | 20 (100) | <0.01 |
| Beta-blocker (%) | 35 (85.3) | 20 (100) | <0.01 |
| Antiarrhythmic drugs | |||
| Amiodarone (%) | 9 (21.9) | 4 (20) | 0.44 |
| ICD therapy prior to generator replacement (%) | 13 (31.7) | 5 (25) | 0.27 |
| ICD therapy after generator replacement (%) | 11 (26.8) | 2 (10) | <0.05 |
ARB, angiotensin receptor blocker; CRT-D, cardiac resynchronisation therapy-defibrillator; ICD, implantable cardioverter-defibrillator; ICM, ischaemic cardiomyopathy; LVEF, left ventricular ejection fraction; NICM, non-ischaemic cardiomyopathy; TIA, transient ischaemic attack; eGFR, estimated glomerular filtration rate.