Table 1

Patients’ baseline characteristics and study description

Study*	Year	Antiplatelet	ACS type	Treatment	Morphine dosing	Group	Patient number	Age (year)	Male %	MI history %	DM %	HTN %	Smoking %
Meine et al 10	2005	Clopidogrel (40%)	NSTEMI	66% had early angiogram	Intravenous on presentation	Morphine	17 003	65	62	33	32	67	33
Meine et al 10	2005	Clopidogrel (40%)	NSTEMI	66% had early angiogram	Intravenous on presentation	No morphine	40 036	70	59	31	33	70	25
Puymirat et al 2	2016	Clopidogrel (100%)	STEMI	PCI	Intravenous on presentation	Morphine	453	59	81	11	12	39	53
Puymirat et al 2	2016	Clopidogrel (100%)	STEMI	PCI	Intravenous on presentation	No morphine	1985	64	73	11	17	50	38
Kubica et al 5	2016	Ticagrelor (100%)	STEMI and NSTEMI	PCI	Intravenous on presentation	Morphine	35	61	66	14	23	43	55
Kubica et al 5	2016	Ticagrelor (100%)	STEMI and NSTEMI	PCI	Intravenous on presentation	No morphine	35	63	80	23	14	60	45
Parodi et al 6	2015	Ticagrelor (68%) and prasugrel (32%)	STEMI	PCI	Not specified	Morphine	205	62	73	9	53	49	57
Parodi et al 6	2015	Ticagrelor (68%) and prasugrel (32%)	STEMI	PCI	Not specified	No morphine	95	61	79	7	15	54	53
Bellandi et al 3	2016	Ticagrelor (72%) and prasugrel (28%)	STEMI	PCI	Not specified	Morphine	108	64	73	8	45	55	49
Bellandi et al 3	2016	Ticagrelor (72%) and prasugrel (28%)	STEMI	PCI	Not specified	No morphine	74	64	76	8	16	66	45
Mccarthy et al 9	2017	Clopidogrel (77%) and ticagrelor (18%)	STEMI and NSTEMI	PCI	Not specified	Morphine	783	62	76	31	28	68	30
Mccarthy et al 9	2017	Clopidogrel (77%) and ticagrelor (18%)	STEMI and NSTEMI	PCI	Not specified	No morphine	2244	65	74	24	23	66	24
Bonin et al 7	2018	Not specified	STEMI	PCI	Not specified	Morphine	554	59	82	6	13	38	43
Bonin et al 7	2018	Not specified	STEMI	PCI	Not specified	No morphine	413	61	82	5	13	37	41
Farag et al 8	2018	Clopidogrel (86%) and ticagrelor (14%)	STEMI	PCI	Intravenous prehospital	Morphine	218	64	78	11	16	49	34
Farag et al 8	2018	Clopidogrel (86%) and ticagrelor (14%)	STEMI	PCI	Intravenous prehospital	No morphine	82	63	80	12	22	54	29

*All study reported in-hospital outcomes except Bonin et al.
ACS, acute coronary syndrome; NSTEMI, non-ST elevation myocardial infarction; PCI, percutaneous coronary intervention; STEMI, ST elevation myocardial infarction.