Allergic and anaphylactic reactions following BPG administration for RHD prophylaxis
| Study | Year | Demographics | Allergic reactions | Anaphylactic reactions | Fatalities | ||
| Number of events (total patients) | % | Number of events (total patients) | % | ||||
| Stollerman et al15 | 1952 | Children (6–14 years) | 4 (135) | 3.0 | 0 (135) | 0 | 0 |
| Diehl et al43 | 1954 | Children (5–20 years) | 2 (96) | 2.1 | 0 (96) | 0 | 0 |
| Stollerman et al15 | 1955 | Children (6–16 years) | 5 (410) | 1.2 | 0 (410) | 0 | 0 |
| Hsu and Evans16 | 1958 | Adults (20–54 years) | 6 (32) | 18.7 | 1 (32) | 3.1 | 1 |
| Steigmann and Suker17 | 1962 | Adults (19yo, 49yo, ‘middle-aged woman’) | N/A | N/A | 3 (3) | 100 | 3 |
| Lue et al10 | 1976 | Children (age not specified) | 7 (105) | 6.7 | 2 (105) | 1.9 | N/R |
| Markowitz and Lue39 | 1991 | Children and adults (5–28 years) | 57 (1792) | 3.2 | 4 (1792) | 0.2 | 1 |
| WHO44 | 2000 | Children (10–14 years) | N/A | N/A | 2 (2) | 100 | 2 |
| Regmi and Upadhyaya21 | 2011 | Children and adults (age not specified) | 65 (4712) | 1.4 | 5 (4712) | 0.1 | 0 |
| Kaya et al22 | 2014 | Children (5–16 years) | 11 (535) | 2.1 | 0 (535) | 0 | 0 |
| Sani et al24 | 2015 | Children (0–15 years) | N/A | N/A | 1 (47) | N/A | 0 |
| Kalani et al23 | 2016 | Adults (40yo) | N/A | N/A | 1 (1) | N/A | 1 |
| Berkovitch et al11 | 2018 | Children and adults (10–91 years) | N/A | N/A | 2 (2) | N/A | 2 |
| Total | 157 | 21 | 10 | ||||
BPG, benzathine penicillin G; N/R, not reported; RHD, rheumatic heart disease.