Table 3

Indicators of Stroke/Systolic Embolism/Major Bleeding/All-Cause Mortality

FactorUnivariateMultivariate
HR95% CIP valueHR95% CIP value
Age1.081.04 to 1.13<0.001
Female3.361.71 to 6.62<0.0013.491.73 to 7.070.001
Weight0.960.93 to 0.990.004
Hypertension2.000.94 to 4.240.067
Diabetes mellitus0.670.26 to 1.730.408
Heart failure2.251.17 to 4.330.012
Stroke/TIA1.430.75 to 2.730.274
Bleeding history1.930.59 to 6.300.270
eGFR0.990.98 to 1.010.348
Hb0.730.62 to 0.86<0.001
Albumin0.400.26 to 0.63<0.0010.470.28 to 0.790.005
Frail5.722.60 to 12.6<0.0013.711.59 to 8.650.002
Malignancy3.371.59 to 7.160.0014.021.83 to 8.840.001
Under-dosed2.460.74 to 8.230.130
Over-dosed0.570.08 to 4.160.574
CHA2DS2-VASc score1.411.17 to 1.71<0.001
HAS-BLED score1.571.12 to 2.200.009
  • Frail: CFS score of 5–9.

  • Hb, haemoglobin; TIA, transient ischaemic attack; eGFR, estimated glomerular filtration rate.