Reperfusion in acute myocardial infarction: Effect of timing and modulating factors in experimental models☆
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2015, The LancetCitation Excerpt :Door-to-balloon (D2B) time predicts survival in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI).1–3 This relation has been thought to be causal, supported by studies in animals4 and observational evidence5,6 indicating that shorter times to reperfusion are linked to decreased myocardial damage and mortality. As a result, clinical guidelines and national quality initiatives in the past decade have focused on shortening D2B times, including the large D2B Alliance sponsored by the American College of Cardiology (ACC) and the Mission:Lifeline Program led by the American Heart Association (AHA).7–9
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Supported in part by National Institutes of Health grants HL-27416, HL-23138 and HL-17670.
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Present address Vincent J. Richard is Service de Pharmacologie, CHU de Rouen, Hopital de Bois Guillaume, BP100, 76233 Bois Guillaume Cedex, France.