Review sectionHepatic peroxisome proliferation in rodents and its significance for humans
References (275)
- et al.
Lipid-metabolising enzymes, CoASH and long-chain acyl-CoA in rat liver after treatment with tiadenol, nicotinic acid and niadenate
Biochemical Pharmacology
(1982) - et al.
Induction of peroxisomal enzymes and palmitoyl-CoA hydrolase in rats treated with cholestyramine and nicotinic acid
Biochemical Pharmacology
(1984) - et al.
Influence of valproic acid on hepatic carbohydrate and lipid metabolism
Archives of Biochemistry and Biophysics
(1983) - et al.
Effects of chronic treatment with the Leukotriene D4-antagonist compound LY-171883 on B6C3F1 mice
Fundamental and Applied Toxicology
(1990) - et al.
Species differences in the response of cultured hepatocytes to phthalate esters
Food and Chemical Toxicology
(1986) - et al.
Correlation between the cellular level of long-chain acyl-CoA, peroxisomal β-oxidation and palmitoyl-CoA hydrolase activity in rat liver
- et al.
Alkylthio acetic acids (3-thio fatty acids)—a new group of non-β-oxidizable peroxisome-inducing fatty acid analogues
- et al.
Enzymatic changes in rat liver associated with low and high doses of a peroxisome proliferator
Toxicology and Applied Pharmacology
(1984) Inositol lipids and cell proliferation
Biochemica et Biophysica Acta
(1987)- et al.
Toxicological studies on a benzofuran derivative: III. Comparison of peroxisome proliferation in rat and human hepatocytes in primary culture
Toxicology and Applied Pharmacology
(1990)
Studies on the mechanism of induction of microsomal cytochrome P450 and peroxisomal bifunctional enzyme mRNAs by nafenopin in primary cultures of adult rat hepatocytes
Biochemical Pharmacology
The significance of in vitro studies on peroxisomal proliferation
Toxicology in Vitro
The effect of beclobric acid and clofibric acid on peroxisomal β-oxidation and peroxisome proliferation in primary cultures of rat, monkey and human hepatocytes
Biochemical Pharmacology
Influence of fenofibrate on cellular and subcellular liver structure in hyperlipidemic patients
Atherosclerosis
Increased activity of peroxisomal β-oxidation in rat liver caused by ethyl 2[5(4-chlorophenyl)pentyl]-oxirane-2-carboxylate; an inhibitor of mitochondrial β-oxidation
Biochemical and Biophysical Research Communications
Metabolism of very long chain monounsaturated fatty acids (22:1) and the adaptation to their presence in the diet
Journal of Lipid Research
Toxicological studies on a benzofurane derivative
Stimulation of fatty acid utilisation by sodium clofibrate in rat and monkey hepatocytes
Biochemical Pharmacology
Association of persistent peroxisome proliferation and oxidative injury with hepatococarcinogenicity in female F-344 rats fed di(2-ethylhexyl)phthalate for 2 years
Cancer Letters
Failure of the peroxisome proliferator WY-14,643 to initiate growth-selectable foci in rat liver
Toxicology
Review of the hepatic response to hypolipidaemic drugs in rodents and assessment of its toxicological significance to man
Food and Cosmetics Toxicology
Vitamin E deficiency as hepatic peroxisomal proliferator: electron microscopic evidence
Cell Biology International Reports
Inhibition of development of preneoplastic lesions in the livers of rats fed a weakly carcinogenic environmental contaminant
Cancer Letters
Light and electron microscopy of liver in hyperlipoproteinemic patients under long-term Gemfibrozil treatment
Atherosclerosis
Control of the peroxisomal beta oxidation pathway by a novel family of nuclear hormone receptors
Cell
Hepatic peroxisomal changes induced by a tetrazole-substituted alkoxyacetophenone in rats and comparison with other species
Toxicology and Applied Pharmacology
Induction of peroxisomal β-oxidation in the rat liver in vivo and in vitro by tetrazole-substituted acetophenones: structure-activity relationships
Toxicology and Applied Pharmacology
Biochemical, histological and ultrastructural changes in rat and mouse liver following the administration of trichlorethylene; possible relevance to species differences in hepatocarcinogenicity
Toxicology and Applied Pharmacology
Preclinical toxicology studies with the lipid-regulating agent gemcadiol
Fundamental and Applied Toxicology
Cetaben versus clofibrate comparison of toxicity and peroxisome proliferation in rats
Toxicology
Effect of ciprofibrate, benzafibrate and LY171883 on peroxisomal β-oxidation in cultured rat, dog, and rhesus monkey hepatocytes
Toxicology and Applied Pharmacology
Effects of dietary di(2-ethylhexyl) phthalate on the structure and function of rat hepatocytes
Biochemica et Biophysica Acta
Morphometric study of human hepatic cell modifications induced by fenofibrate
Metabolism
Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis
Cancer Letters
Lack of covalent binding of peroxisome proliferators nafenopin and Wy-14 643 to DNA in vivo and in vitro
Toxicology Letters
Chlorinated hydrocarbon-induced peroxisomal enzyme activity in relation to species and organ carcinogenicit
Toxicology and Applied Pharmacology
Peroxisome proliferation in cultured rat hepatocytes produced by clofibrate and phthalic ester metabolites
Toxicology Letters
Relationship between morphological changes and lipid-lowering action of p-chlorophenoxyisobutyric acid (CPIB) on hepatic mitochondria and peroxisomes in man
Atherosclerosis
Isolation, complementary DNA sequence and regulation of rat hepatic lauric acid Ω-oxidation (cytochrome P-450)
Journal of Biological Chemistry
Action of clofibrate and its analogs in rats
Comparative studies on peroxisomal enzyme induction in hepatocytes from rat, cynomolgus monkey and human by hypolipidaemic drugs
Toxicologist
Cell replication and unscheduled DNA synthesis (UDS) activity of low molecular weight chlorinated paraffins in the rat liver in vivo
Mutagenesis
Structure activity relationships of clofibrate-like compounds on lipid metabolism
Peroxisome induction studies on seven phthalate esters
Toxicology and Industrial Health
Effects of isoprenaline treatment on the rat liver parenchyma
Acta analytica
Electron microscopy of rat liver after carbon tetrachloride poisoning
Experimental Cell Research
Localisation and differential induction of cytochrome P450IVA and acyl CoA oxidase in rat liver
Biochemical Journal
Induction of acyl CoA oxidase and P450IVA1 in rat primary hepatocyte cultures by peroxisome proliferators
Biochemical Journal
Investigations on the mechanism of liver tumour induction by peroxisome proliferators
Archives of Toxicology
Mechanisms of tumour induction by peroxisome proliferators
Archives of Toxicology
Cited by (269)
Carcinogenicity
2018, Comprehensive Toxicology: Third EditionHistopathological image analysis of chemical-induced hepatocellular hypertrophy in mice
2016, Experimental and Toxicologic PathologyOral repeated-dose systemic and reproductive toxicity of 6:2 FLUOROTELOMER alcohol in mice
2015, Toxicology ReportsLiver tumor formation in female rat induced by fluopyram is mediated by CAR/PXR nuclear receptor activation
2014, Regulatory Toxicology and PharmacologyPeroxisome proliferator-activated receptor-α activation and excess energy burning in hepatocarcinogenesis
2014, BiochimieCitation Excerpt :As shown in Fig. 2, under these conditions, human hepatocytes did show an observable increase in the number of peroxisomes when treated with ciprofibrate [34]. Some other studies showed that peroxisome proliferators have little effect, if any, on human liver cells [68–70]. Although preliminary in nature these observations suggest that additional rigorous studies are needed to extend this work.
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Present address: Ciba-Geigy, CH-4002, Basel, Switzerland
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Present address: Zeneca CTL, Alderley Park, Macclesfield, Cheshire SK104TJ, UK
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Present address: Robens Institute of Health and Safety, University of Surrey, Guildford GU2 5XH
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Present address: ECETOC, Av. E. Van Nieuwenhuyse 4 (Bte 6), B-1160 Brussels, Belgium
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Present address: Hüls AG, 45764, Germany.