Clinical TrialImpact of Dopamine Infusion on Renal Function in Hospitalized Heart Failure Patients: Results of the Dopamine in Acute Decompensated Heart Failure (DAD-HF) Trial
Section snippets
Setting
The Dopamine in Acute Decompensated Heart Failure (DAD-HF) trial was a randomized double-blind study including patients hospitalized with ADHF in two Greek centers: a tertiary academic medical center (Larissa University Hospital, Larissa, Greece) and a general hospital (General Hospital of Volos, Volos, Greece).
Patient Population
ADHF patients with New York Heart Association (NYHA) functional class IV symptoms admitted between January 2009 and December 2009 were included in this study. Inclusion in the study
Baseline Patient Characteristics
The baseline characteristics of the study population are presented in Table 1. Admission systolic blood pressure was higher in the HDF than in the LDFD group (176 ± 33 vs. 157 ± 28 mm Hg; P = .031). No other significant differences between the two groups regarding demographics, clinical/hemodynamic variables, coexisting morbidities, and medications were observed.
Treatment Effects
During the 8 hours of protocol treatment, systolic, diastolic, and mean blood pressure as well as heart rate decreased significantly
Discussion
The results of this study show that the combination of low-dose furosemide and low-dose dopamine infusion is as effective as the high-dose furosemide infusion in terms of clinical and diuretic response in patients hospitalized for ADHF. More importantly, however, the combination of low-dose furosemide and low-dose dopamine infusion is associated with significantly lower rates of WRF than high-dose furosemide, suggesting a renoprotective effect in this patient population.
Although a clear signal
Disclosures
None.
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