Mortality Risk Attributable to Atrial Fibrillation in Middle-Aged and Elderly People in the Japanese General Population Nineteen-Year Follow-up in NIPPON DATA80

Masaki Ohsawa; Akira Okayama; Tomonori Okamura; Kazuyoshi Itai; Motoyuki Nakamura; Kozo Tanno; Karen Kato; Yumi Yaegashi; Toshiyuki Onoda; Kiyomi Sakata; Hirotsugu Ueshima; The NIPPON DATA80 Research Group

doi:10.1253/circj.71.814

Clinical Investigation

Mortality Risk Attributable to Atrial Fibrillation in Middle-Aged and Elderly People in the Japanese General Population

Nineteen-Year Follow-up in NIPPON DATA80

Masaki Ohsawa, Akira Okayama, Tomonori Okamura, Kazuyoshi Itai, Motoyuki Nakamura, Kozo Tanno, Karen Kato, Yumi Yaegashi, Toshiyuki Onoda, Kiyomi Sakata, Hirotsugu Ueshima, The NIPPON DATA80 Research Group

Author information

Masaki Ohsawa
Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University
Akira Okayama
Department of Preventive Cardiology, National Cardiovascular Center
Tomonori Okamura
Department of Health Science, Shiga University of Medical Science
Kazuyoshi Itai
Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University
Motoyuki Nakamura
Department of Internal Medicine II, School of Medicine, Iwate Medical University
Kozo Tanno
Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University
Karen Kato
Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University
Yumi Yaegashi
Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University
Toshiyuki Onoda
Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University
Kiyomi Sakata
Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University
Hirotsugu Ueshima
Department of Health Science, Shiga University of Medical Science
The NIPPON DATA80 Research Group
Members of the NIPPON DATA80 Research Group are listed in Appendix 1

Keywords: Atrial fibrillation, Japanese, Mortality, Stroke

JOURNAL FREE ACCESS

2007 Volume 71 Issue 6 Pages 814-819

DOI https://doi.org/10.1253/circj.71.814

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Abstract

Background The extent to which atrial fibrillation (AF) contributes to mortality in the Japanese general population has not been clarified. Methods and Results A randomly sampled general population from all over Japan (4,154 men, 5,329 women; age ≥30 years) was enrolled. Single electrocardiogram recordings were taken in the baseline survey. Stroke death, cardiovascular deaths and all-cause deaths during the subsequent 19 years were analyzed by the presence of AF at baseline. Cox's regression analysis was carried out to estimate the hazard ratios (HRs) of each cause of death attributable to AF after adjusting for other risk factors. Prevalence of AF was 0.64% in the study. The observed person-years were 162,980 among persons without AF and 699 among persons with AF. There were 1,919 deaths. Multivariate adjusted HRs for stroke death, cardiovascular death and all-cause death were 2.69, 2.76 and 1.88, respectively (p<0.05). These HRs were 14.7, 9.63 and 4.00 among persons aged 64 years or younger (p<0.05). Conclusion AF affects stroke mortality, cardiovascular mortality and all-cause mortality in the Japanese general population. Careful attention should be paid to persons with AF in order to prevent future cardiovascular events. (Circ J 2007; 71: 814 - 819)

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