Abstract
A longitudinal study of cognitive function after coronary artery bypass surgery examined 107 participants using 11 tests, preoperatively and at 6 days, 8 weeks, and 5 years after surgery. The overall neuropsychological (NP) change score declined at 6 days, showed some recovery at 8 weeks, and declined again at 5 years. The number of microemboli recorded during surgery, postoperative short-term cognitive change, and degree of recovery at 8 weeks were identified as predictors of change in NP score to 5 years. This suggests that even over a 5-year period, operative damage is detectable. Patients' vulnerability to short-term deterioration and resilience or ability to recover over a few weeks from operative cerebral insult are important processes of unknown mechanisms.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / therapeutic use
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Adolescent
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Adult
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Aged
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Cardiopulmonary Bypass / adverse effects
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Cardiopulmonary Bypass / psychology
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Cognition / physiology*
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Cognition Disorders / diagnosis
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Cognition Disorders / etiology*
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Coronary Artery Bypass / adverse effects*
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Coronary Artery Bypass / psychology*
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Double-Blind Method
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Female
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Humans
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Intracranial Embolism / drug therapy
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Intracranial Embolism / etiology
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Intracranial Embolism / prevention & control
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Longitudinal Studies
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Male
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Middle Aged
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Neuroprotective Agents / therapeutic use
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Neuropsychological Tests
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Postoperative Complications / psychology*
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Postoperative Period
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Time Factors
Substances
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Acetamides
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Neuroprotective Agents
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remacemide