[HTML][HTML] Overview of microRNAs in cardiac hypertrophy, fibrosis, and apoptosis

J Wang, OW Liew, AM Richards, YT Chen - International journal of …, 2016 - mdpi.com
MicroRNAs (miRNAs) are non-coding RNAs that play essential roles in modulating the gene
expression in almost all biological events. In the past decade, the involvement of miRNAs in …

[HTML][HTML] MicroRNA and heart failure

LL Wong, J Wang, OW Liew, AM Richards… - International journal of …, 2016 - mdpi.com
Heart failure (HF) imposes significant economic and public health burdens upon modern
society. It is known that disturbances in neurohormonal status play an important role in the …

[HTML][HTML] Extracellular vesicles in cardiovascular diseases: alternative biomarker sources, therapeutic agents, and drug delivery carriers

SY Chong, CK Lee, C Huang, YH Ou… - International journal of …, 2019 - mdpi.com
Cardiovascular diseases (CVD) represent the leading cause of morbidity and mortality
globally. The emerging role of extracellular vesicles (EVs) in intercellular communication …

Obstructive sleep apnea and cardiovascular events after percutaneous coronary intervention

CH Lee, R Sethi, R Li, HH Ho, T Hein, MH Jim, G Loo… - Circulation, 2016 - Am Heart Assoc
Background—There is a paucity of data from large cohort studies examining the prognostic
significance of obstructive sleep apnea (OSA) in patients with coronary artery disease. We …

Right ventricular dysfunction in left‐sided heart failure with preserved versus reduced ejection fraction

L Bosch, CSP Lam, L Gong, SP Chan… - European journal of …, 2017 - Wiley Online Library
Background Right ventricular (RV) dysfunction is recognized as a major prognostic factor in
left‐sided heart failure (HF). However, the relative contribution of RV dysfunction in HF with …

A landscape of circular RNA expression in the human heart

WLW Tan, BTS Lim, CGO Anene-Nzelu… - Cardiovascular …, 2017 - academic.oup.com
Aims Circular RNA (circRNA) is a newly validated class of single-stranded RNA,
ubiquitously expressed in mammalian tissues and possessing key functions including acting …

Growth differentiation factor 15, ST2, high‐sensitivity troponin T, and N‐terminal pro brain natriuretic peptide in heart failure with preserved vs. reduced ejection …

R Santhanakrishnan, JPC Chong, TP Ng… - European journal of …, 2012 - Wiley Online Library
Aims Growth differentiation factor 15 (GDF15), ST2, high‐sensitivity troponin T (hsTnT), and
N‐terminal pro brain natriuretic peptide (NT‐proBNP) are biomarkers of distinct mechanisms …

Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction

LL Wong, A Armugam, S Sepramaniam… - European journal of …, 2015 - Wiley Online Library
Aim The potential diagnostic utility of circulating microRNAs in heart failure (HF) or in
distinguishing HF with reduced vs. preserved left ventricular ejection fraction (HFREF and …

Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study

BT Santema, W Ouwerkerk, J Tromp, IE Sama… - The Lancet, 2019 - thelancet.com
Background Guideline-recommended doses of angiotensin-converting-enzyme (ACE)
inhibitors or angiotensin-receptor blockers (ARBs), and β blockers are similar for men and …

[PDF][PDF] Large-scale whole-genome sequencing of three diverse Asian populations in Singapore

D Wu, J Dou, X Chai, C Bellis, A Wilm, CC Shih… - Cell, 2019 - cell.com
Underrepresentation of Asian genomes has hindered population and medical genetics
research on Asians, leading to population disparities in precision medicine. By whole …