User profiles for "author:Harry Klimis"

Harry Klimis

Clinical Lecturer, University of Sydney
Verified email at sydney.edu.au
Cited by 662

Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with …

CK Chow, ER Atkins, GS Hillis, MR Nelson, CM Reid… - The Lancet, 2021 - thelancet.com
Background Treatment inertia is a recognised barrier to blood pressure control, and simpler,
more effective treatment strategies are needed. We hypothesised that a hypertension …

Breaking barriers: mobile health interventions for cardiovascular disease

H Klimis, J Thakkar, CK Chow - Canadian Journal of Cardiology, 2018 - Elsevier
Cardiovascular disease (CVD) is a leading global cause of death and morbidity and
prevention needs to be strengthened to tackle this. Mobile health (mHealth) might present a …

Diagnostic accuracy of handheld electrocardiogram devices in detecting atrial fibrillation in adults in community versus hospital settings: a systematic review and meta …

KC Wong, H Klimis, N Lowres, A von Huben… - Heart, 2020 - heart.bmj.com
With increasing use of handheld ECG devices for atrial fibrillation (AF) screening, it is
important to understand their accuracy in community and hospital settings and how it differs …

Machine-learning versus traditional approaches for atherosclerotic cardiovascular risk prognostication in primary prevention cohorts: a systematic review and meta …

W Liu, L Laranjo, H Klimis, J Chiang… - … Journal-Quality of …, 2023 - academic.oup.com
Background Cardiovascular disease (CVD) risk prediction is important for guiding the
intensity of therapy in CVD prevention. Whilst current risk prediction algorithms use …

Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins?

ST Nevin, RJ Clark, H Klimis, MJ Christie, DJ Craik… - Molecular …, 2007 - ASPET
The synthetic α-conotoxin Vc1. 1 is a small disulfide bonded peptide currently in
development as a treatment for neuropathic pain. Unlike Vc1. 1, the native post …

Text messages to improve medication adherence and secondary prevention after acute coronary syndrome: the TEXTMEDS randomized clinical trial

CK Chow, H Klimis, A Thiagalingam, J Redfern… - Circulation, 2022 - Am Heart Assoc
Background: TEXTMEDS (Text Messages to Improve Medication Adherence and Secondary
Prevention After Acute Coronary Syndrome) examined the effects of text message–delivered …

A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain

H Klimis, DJ Adams, B Callaghan, S Nevin… - PAIN®, 2011 - Elsevier
α-Conotoxins that are thought to act as antagonists of nicotinic acetylcholine receptors
(nAChRs) containing α3-subunits are efficacious in several preclinical models of chronic …

Intrathecal α-conotoxins Vc1. 1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain

IA Napier, H Klimis, BK Rycroft, AH Jin, PF Alewood… - …, 2012 - Elsevier
The large diversity of peptides from venomous creatures with high affinity for molecules
involved in the development and maintenance of neuropathic pain has led to a surge in …

Text messages for primary prevention of cardiovascular disease: the TextMe2 randomized clinical trial

H Klimis, A Thiagalingam, D McIntyre, S Marschner… - American Heart …, 2021 - Elsevier
Background Primary prevention guidelines emphasize the importance of lifestyle
modification, but many at high-risk have suboptimal cardiovascular risk factor (CVRF) …

The burden of uncontrolled cardiovascular risk factors in men with prostate cancer: a RADICAL-PC analysis

H Klimis, JH Pinthus, N Aghel, E Duceppe, V Fradet… - Cardio Oncology, 2023 - jacc.org
Background Cardiovascular disease (CVD) incidence is higher in men with prostate cancer
(PC) than without. Objectives We describe the rate and correlates of poor cardiovascular risk …