[HTML][HTML] Cardiovascular outcomes and hospitalizations in Asian patients receiving immune checkpoint inhibitors: a population-based study

JSK Chan, I Lakhani, TTL Lee, OHI Chou… - Current Problems in …, 2023 - Elsevier
Immune checkpoint inhibitors (ICI) have known associations with cardiotoxicity. However, a
representative quantification of the adverse cardiovascular events and cardiovascular …

Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis

I Lakhani, M Gong, WT Wong, G Bazoukis… - Metabolism, 2018 - Elsevier
Background Fibroblast growth factor 21 is a signalling protein involved in cell differentiation,
morphogenesis, proliferation and metabolism. Recent studies have associated increased …

[HTML][HTML] Diagnostic and prognostic value of serum C-reactive protein in heart failure with preserved ejection fraction: a systematic review and meta-analysis

I Lakhani, MV Wong, JKF Hung, M Gong, KB Waleed… - Heart failure …, 2021 - Springer
Heart failure (HF) is a major epidemic with rising morbidity and mortality rates that encumber
global healthcare systems. While some studies have demonstrated the value of CRP in …

Territory-wide cohort study of Brugada syndrome in Hong Kong: predictors of long-term outcomes using random survival forests and non-negative matrix factorisation

S Lee, J Zhou, KHC Li, KSK Leung, I Lakhani, T Liu… - Open …, 2021 - openheart.bmj.com
Objectives Brugada syndrome (BrS) is an ion channelopathy that predisposes affected
patients to spontaneous ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac …

Multi‐modality machine learning approach for risk stratification in heart failure with left ventricular ejection fraction≤ 45%

G Tse, J Zhou, SWD Woo, CH Ko, RWC Lai… - ESC heart …, 2020 - Wiley Online Library
Aims Heart failure (HF) involves complex remodelling leading to electrical and mechanical
dysfunction. We hypothesized that machine learning approaches incorporating data …

Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE−/− Mice

Y Wu, F Song, Y Li, J Li, Y Cui, Y Hong… - Journal of cellular …, 2021 - Wiley Online Library
Oxidative stress has a considerable influence on endothelial cell dysfunction and
atherosclerosis. Acacetin, an anti‐inflammatory and antiarrhythmic, is frequently used in the …

Association of NPAC score with survival after acute myocardial infarction

CKH Li, Z Xu, J Ho, I Lakhani, YZ Liu, G Bazoukis, T Liu… - Atherosclerosis, 2020 - Elsevier
Background and aims Risk stratification in acute myocardial infarction (AMI) is important for
guiding clinical management. Current risk scores are mostly derived from clinical trials with …

[HTML][HTML] Novel mechanisms in heart failure with preserved, midrange, and reduced ejection fraction

I Lakhani, KSK Leung, G Tse, APW Lee - Frontiers in Physiology, 2019 - frontiersin.org
Heart failure (HF) represents a major epidemic with high morbidity and mortality rates,
imposing a significant burden on healthcare systems worldwide (Savarese and Lund, 2017) …

[HTML][HTML] Adverse Cardiovascular Complications following prescription of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors: a …

J Zhou, S Lee, I Lakhani, L Yang, T Liu, Y Zhang, Y Xia… - Cardio-Oncology, 2022 - Springer
Abstract Background Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1)
inhibitors, such as pembrolizumab, nivolumab and atezolizumab, are major classes of …

[HTML][HTML] P-Wave Area Predicts New Onset Atrial Fibrillation in Mitral Stenosis: A Machine Learning Approach

G Tse, I Lakhani, J Zhou, KHC Li, S Lee… - … in Bioengineering and …, 2020 - frontiersin.org
Introduction: Mitral stenosis is associated with an atrial cardiomyopathic process, leading to
abnormal atrial electrophysiology, manifesting as prolonged P-wave duration (PWD), larger …