Recent progress in molecular biology has provided new techniques for inhibiting target
gene expression. In particular, the application of DNA technology, such as antisense …

The Japanese Society of Hypertension guidelines for the management of hypertension (JSH
2014) — Keio University Skip to main navigation Skip to search Skip to main content Keio …

3. Morbidity and mortality rates due to diseases such as stroke, myocardial infarction, heart
disease and chronic renal disease increase with elevating blood pressure. The effects of …

The transcriptional factor nuclear factor-κ B (NF κ B) plays a pivotal role in the coordinated
trans-activation of cytokine and adhesion molecule genes that might be involved in …

The mechanisms through which hypertension contributes to the occurrence of myocardial
infarction should be discussed from two points of view:(1) common risk factors for the two …

Hepatocyte growth factor (HGF) exclusively stimulates the growth of endothelial cells without
replication of vascular smooth muscle cells and acts as a survival factor against endothelial …

The objective of this investigation was to evaluate the role of hypertension in endothelial
function, changes in which are known to be an early event of atherosclerosis. We assessed …

Background—The Framingham Study recently revealed that the homozygous deletion
polymorphism of the angiotensin-converting enzyme gene (ACE DD) is associated with …

Background We have demonstrated that accumulated macrophages in human coronary
arteries strongly express angiotensin converting enzyme in accordance with the …

Aortic stiffness measured by aorta-iliac or carotid-femoral pulse wave velocity (PWV)
predicts all-cause and cardiovascular mortality. Brachial-ankle PWV (baPWV) has been …